Open Access

Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy

  • Authors:
    • Jionghua Huang
    • He Huang
    • Wei Pan
    • Dejin Ou
    • Wenjun Dai
    • Yuhui Lin
    • Jinlei Wu
    • Wenjie Xie
    • Ximing Chen
  • View Affiliations

  • Published online on: June 15, 2017     https://doi.org/10.3892/mmr.2017.6790
  • Pages: 2023-2029
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It has been suggested that renal denervation (RD) may attenuate left ventricular (LV) hypertrophy. However, the role that autophagy serves in this process is currently unclear. In the present study, utilizing a model of hypertension‑induced cardiac hypertrophy in spontaneous hypertensive rats, it was demonstrated that RD was significantly associated with a reduction in LV hypertrophy. Furthermore, a decrease in the myocardial mRNA of hypertrophy‑associated genes was demonstrated in RD rats compared with sham controls. In addition, RD in hypertension‑induced LV hypertrophy rats was associated with the attenuation of cellular autophagic response over activation at a physiological level. This was indicated by a reduction in the expression of Beclin‑1, autophagy related 9A and microtubule‑associated protein 1A/1B-light chain 3 II/I in RD rats to physiological levels that are observed in control rats. Furthermore, the number of autophagosomes was restored to physiological levels in the cardiomyocytes of RD rats. The results of the current study suggest that RD may attenuate LV hypertrophy via the regulation of autophagic responses.
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August-2017
Volume 16 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Huang J, Huang H, Pan W, Ou D, Dai W, Lin Y, Wu J, Xie W and Chen X: Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy. Mol Med Rep 16: 2023-2029, 2017
APA
Huang, J., Huang, H., Pan, W., Ou, D., Dai, W., Lin, Y. ... Chen, X. (2017). Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy. Molecular Medicine Reports, 16, 2023-2029. https://doi.org/10.3892/mmr.2017.6790
MLA
Huang, J., Huang, H., Pan, W., Ou, D., Dai, W., Lin, Y., Wu, J., Xie, W., Chen, X."Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy". Molecular Medicine Reports 16.2 (2017): 2023-2029.
Chicago
Huang, J., Huang, H., Pan, W., Ou, D., Dai, W., Lin, Y., Wu, J., Xie, W., Chen, X."Renal denervation attenuates cardiac hypertrophy in spontaneously hypertensive rats via regulation of autophagy". Molecular Medicine Reports 16, no. 2 (2017): 2023-2029. https://doi.org/10.3892/mmr.2017.6790