Ameliorative efficacy of quercetin against cisplatin‑induced mitochondrial dysfunction: Study on isolated rat liver mitochondria

  • Authors:
    • Mohammad Waseem
    • Heena Tabassum
    • Monica Bhardwaj
    • Suhel Parvez
  • View Affiliations

  • Published online on: June 27, 2017     https://doi.org/10.3892/mmr.2017.6860
  • Pages: 2939-2945
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to investigate the hepatoprotective effects of the bioflavonoid quercetin (QR) on cisplatin (CP)‑induced mitochondrial oxidative stress in the livers of rats, to elucidate the role of mitochondria in CP‑induced hepatotoxicity, and its underlying mechanism. Isolated liver mitochondria were incubated with 100 µg/ml CP and/or 50 µM QR in vitro. CP treatment triggered a significant increase in membrane lipid peroxidation (LPO) levels, protein carbonyl (PC) contents, and a decrease in reduced glutathione (GSH) and non‑protein thiol (NP‑SH) levels. In addition, CP caused a marked decline in the activities of enzymatic antioxidants and mitochondrial complexes (I, II, III and V) in liver mitochondria. QR pre‑treatment significantly modulated the activities of enzymatic antioxidants and mitochondrial complex enzymes. Furthermore, QR reversed the alterations in LPO and PC levels, and GSH and NP‑SH contents in liver mitochondria. The results of the present study suggested that QR supplementation may suppress CP‑induced mitochondrial toxicity during chemotherapy, and provides a potential prophylactic and defensive candidate for anticancer agent‑induced oxidative stress.
View Figures
View References

Related Articles

Journal Cover

September-2017
Volume 16 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Waseem M, Tabassum H, Bhardwaj M and Parvez S: Ameliorative efficacy of quercetin against cisplatin‑induced mitochondrial dysfunction: Study on isolated rat liver mitochondria. Mol Med Rep 16: 2939-2945, 2017.
APA
Waseem, M., Tabassum, H., Bhardwaj, M., & Parvez, S. (2017). Ameliorative efficacy of quercetin against cisplatin‑induced mitochondrial dysfunction: Study on isolated rat liver mitochondria. Molecular Medicine Reports, 16, 2939-2945. https://doi.org/10.3892/mmr.2017.6860
MLA
Waseem, M., Tabassum, H., Bhardwaj, M., Parvez, S."Ameliorative efficacy of quercetin against cisplatin‑induced mitochondrial dysfunction: Study on isolated rat liver mitochondria". Molecular Medicine Reports 16.3 (2017): 2939-2945.
Chicago
Waseem, M., Tabassum, H., Bhardwaj, M., Parvez, S."Ameliorative efficacy of quercetin against cisplatin‑induced mitochondrial dysfunction: Study on isolated rat liver mitochondria". Molecular Medicine Reports 16, no. 3 (2017): 2939-2945. https://doi.org/10.3892/mmr.2017.6860