Adipose‑derived stem cells and hyaluronic acid based gel compatibility, studied in vitro

  • Authors:
    • Jiayan Guo
    • Shu Guo
    • Yuxin Wang
    • Yanqiu Yu
  • View Affiliations

  • Published online on: July 21, 2017     https://doi.org/10.3892/mmr.2017.7055
  • Pages: 4095-4100
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Minimally invasive aesthetic and cosmetic procedures have increased in popularity. Injectable dermal fillers provide soft tissue augmentation, improve facial rejuvenation and wrinkles, and correct tissue defects. To investigate the use of adipose‑derived stem cells integrated with a hyaluronic acid based gel as a dermal filler, the present study used cytotoxicity studies, proliferation studies, adipogenic and osteogenic differentiation, apoptosis assays and scanning electron microscopy. Although hyaluronic acid induced low levels of apoptosis in adipose‑derived stem cells, its significantly promoted proliferation of adipose‑derived stem cells. Hyaluronic acid demonstrates little toxicity against adipose‑derived stem cells. Adipose‑derived stem cells were able to differentiate into adipocytes and osteoblasts. Furthermore, scanning electron microscopy revealed that adipose‑derived stem cells maintained intact structures on the surface of hyaluronic acid as well as in it, and demonstrated abundant cell attachments. The present study demonstrated the compatibility of adipose‑derived stem cells and hyaluronic acid based gels in vitro.

Related Articles

Journal Cover

October-2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Guo J, Guo S, Wang Y and Yu Y: Adipose‑derived stem cells and hyaluronic acid based gel compatibility, studied in vitro. Mol Med Rep 16: 4095-4100, 2017
APA
Guo, J., Guo, S., Wang, Y., & Yu, Y. (2017). Adipose‑derived stem cells and hyaluronic acid based gel compatibility, studied in vitro. Molecular Medicine Reports, 16, 4095-4100. https://doi.org/10.3892/mmr.2017.7055
MLA
Guo, J., Guo, S., Wang, Y., Yu, Y."Adipose‑derived stem cells and hyaluronic acid based gel compatibility, studied in vitro". Molecular Medicine Reports 16.4 (2017): 4095-4100.
Chicago
Guo, J., Guo, S., Wang, Y., Yu, Y."Adipose‑derived stem cells and hyaluronic acid based gel compatibility, studied in vitro". Molecular Medicine Reports 16, no. 4 (2017): 4095-4100. https://doi.org/10.3892/mmr.2017.7055