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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma

  • Authors:
    • Wenyi Zhu
    • Peipei Zhuang
    • Wen Song
    • Shiyu Duan
    • Qiong Xu
    • Man Peng
    • Jun Zhou

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4694-4700
    |
    Published online on: August 4, 2017
       https://doi.org/10.3892/mmr.2017.7175
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Abstract

Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in the development and progression of cancer. Recently HNF1A antisense RNA 1 (HNF1A‑AS1), a lncRNA, has been reported as exhibiting a potential oncogenic role in the development of many types of cancer. However, the expression and the role of HNF1A‑AS1 in colorectal carcinoma (CRC) remains unclear. In the present study, the role of HNF1A‑AS1 in CRC was examined for the first time and its correlation with CRC cell biological behaviors was analyzed. The results demonstrated that HNF1A‑AS1 was distinctly upregulated in CRC tissues and associated with CRC metastasis to the lymph nodes. Reverse transcription‑quantitative polymerase chain reaction revealed that HNF1A‑AS1 was also upregulated in CRC cell lines and localized in the nucleus. In addition, knockdown of HNF1A‑AS1 expression notably inhibited CRC cell proliferation, migration, invasion and colony formation, and suppressed S‑phase entry in vitro. Taken together, these results suggested that HNF1A‑AS1 might serve as a promising prognostic marker for CRC tumorigenesis and progression.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu W, Zhuang P, Song W, Duan S, Xu Q, Peng M and Zhou J: Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma. Mol Med Rep 16: 4694-4700, 2017.
APA
Zhu, W., Zhuang, P., Song, W., Duan, S., Xu, Q., Peng, M., & Zhou, J. (2017). Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma. Molecular Medicine Reports, 16, 4694-4700. https://doi.org/10.3892/mmr.2017.7175
MLA
Zhu, W., Zhuang, P., Song, W., Duan, S., Xu, Q., Peng, M., Zhou, J."Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma". Molecular Medicine Reports 16.4 (2017): 4694-4700.
Chicago
Zhu, W., Zhuang, P., Song, W., Duan, S., Xu, Q., Peng, M., Zhou, J."Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma". Molecular Medicine Reports 16, no. 4 (2017): 4694-4700. https://doi.org/10.3892/mmr.2017.7175
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu W, Zhuang P, Song W, Duan S, Xu Q, Peng M and Zhou J: Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma. Mol Med Rep 16: 4694-4700, 2017.
APA
Zhu, W., Zhuang, P., Song, W., Duan, S., Xu, Q., Peng, M., & Zhou, J. (2017). Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma. Molecular Medicine Reports, 16, 4694-4700. https://doi.org/10.3892/mmr.2017.7175
MLA
Zhu, W., Zhuang, P., Song, W., Duan, S., Xu, Q., Peng, M., Zhou, J."Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma". Molecular Medicine Reports 16.4 (2017): 4694-4700.
Chicago
Zhu, W., Zhuang, P., Song, W., Duan, S., Xu, Q., Peng, M., Zhou, J."Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma". Molecular Medicine Reports 16, no. 4 (2017): 4694-4700. https://doi.org/10.3892/mmr.2017.7175
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