Open Access

Modulation of the immune response in rheumatoid arthritis with strategically released rapamycin

  • Authors:
    • Ping Shao
    • Linxiao Ma
    • Yile Ren
    • Huijie Liu
  • View Affiliations

  • Published online on: August 18, 2017     https://doi.org/10.3892/mmr.2017.7285
  • Pages: 5257-5262
  • Copyright: © Shao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease, which is associated with symptoms, including synovial membrane inflammatory pain, joint synovitis and stiffness. However, there are no effective methods available to cure this disease. In the present study, rapamycin was used to modulate immunity in RA. To limit the cytotoxicity of rapamycin, rapamycin was loaded into well‑characterized biocompatible nanoparticles. In vitro, rapamycin particles downregulated the activation of dendritic cell surface markers, including CD80+ and CD40+, upon interacting with macrophages. The rapamycin particles reduced the secretion of inflammatory cytokines, including interleukin (IL)‑6, tumor necrosis factor (TNF) and IL‑1β, which are characteristic of RA. In vivo, the rapamycin particles decreased the symptoms of RA in mice, and the production of inflammatory cytokines was associated with the occurrence of RA. The present study partially revealed the interactions between rapamycin and two types of immune cell in RA disease, and may potentially offer a solution to improve the treatment of RA.

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October-2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Shao P, Ma L, Ren Y and Liu H: Modulation of the immune response in rheumatoid arthritis with strategically released rapamycin . Mol Med Rep 16: 5257-5262, 2017
APA
Shao, P., Ma, L., Ren, Y., & Liu, H. (2017). Modulation of the immune response in rheumatoid arthritis with strategically released rapamycin . Molecular Medicine Reports, 16, 5257-5262. https://doi.org/10.3892/mmr.2017.7285
MLA
Shao, P., Ma, L., Ren, Y., Liu, H."Modulation of the immune response in rheumatoid arthritis with strategically released rapamycin ". Molecular Medicine Reports 16.4 (2017): 5257-5262.
Chicago
Shao, P., Ma, L., Ren, Y., Liu, H."Modulation of the immune response in rheumatoid arthritis with strategically released rapamycin ". Molecular Medicine Reports 16, no. 4 (2017): 5257-5262. https://doi.org/10.3892/mmr.2017.7285