Open Access

MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB

  • Authors:
    • Xiaolong Xu
    • Fenglin Zhang
    • Xianzhen Chen
    • Qi Ying
  • View Affiliations

  • Published online on: August 21, 2017     https://doi.org/10.3892/mmr.2017.7298
  • Pages: 5326-5332
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioblastoma (GBM) is the most common and aggressive type of primary human brain tumor in China. Dysregulated microRNA (miRNA/miR) expression has been hypothesized to serve a role in the tumorigenesis and progression of human GBM. To explore the potential mechanisms affecting GBM tumorigenesis, the function of miR‑518b in regulating GBM cell proliferation and angiogenesis was examined in vitro by CCK‑8 and tube formation assay and in vivo by xenograft assay. The present study demonstrated that the expression of miR‑518b was downregulated in GBM tissues and in GBM cell lines (U87 and U251). In addition, the expression levels of miR‑518b were highly associated with tumor size, World Health Organization grade and prognosis. Furthermore, overexpression of miR‑518b suppressed GBM cell proliferation and angiogenesis, and induced GBM cell apoptosis in vitro and in vivo. Overexpression of miR‑518b also inhibited the expression of platelet‑derived growth factor receptor β (PDGFRB), and the present study confirmed that the 3' untranslated region (3'UTR) of PDGFRB was a direct target of miR‑518b. In conclusion, to the best of our knowledge, the present study is the first to present evidence suggesting that miR‑518b may serve as a potential marker and target in GBM treatment.

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October-2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Xu X, Zhang F, Chen X and Ying Q: MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB. Mol Med Rep 16: 5326-5332, 2017
APA
Xu, X., Zhang, F., Chen, X., & Ying, Q. (2017). MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB. Molecular Medicine Reports, 16, 5326-5332. https://doi.org/10.3892/mmr.2017.7298
MLA
Xu, X., Zhang, F., Chen, X., Ying, Q."MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB". Molecular Medicine Reports 16.4 (2017): 5326-5332.
Chicago
Xu, X., Zhang, F., Chen, X., Ying, Q."MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB". Molecular Medicine Reports 16, no. 4 (2017): 5326-5332. https://doi.org/10.3892/mmr.2017.7298