Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF‑β1 signaling in articular cartilage in a rodent osteoarthritis model

  • Authors:
    • Wenbo Mu
    • Boyong Xu
    • Hairong Ma
    • Baochao Ji
    • Zhendong Zhang
    • Jiao Li
    • Abdusami Amat
    • Li Cao
  • View Affiliations

  • Published online on: September 20, 2017     https://doi.org/10.3892/mmr.2017.7549
  • Pages: 7679-7684
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Abstract

Osteoarthritis (OA) is the most common degenerative condition of the weight‑bearing joints worldwide without effective medical therapy. In order to investigate whether administration of halofuginone (HF) may attenuate OA, the present study allocated 3‑month‑old male mice into Sham group, vehicle‑treated anterior cruciate ligament transection (ACLT) group and HF‑treated ACLT group. The present study determined that HF treatment reduced the expression of matrix metallopeptidase‑13 and collagen X in articular cartilage. Additionally, it lowered the Osteoarthritis Research Society International‑Modified Mankin score and prevented the loss of articular cartilage from Safranin O and Fast Green staining. HF reduced the progression of osteoarthritis by downregulating abnormally elevated TGF‑β1 activity in articular cartilage. Administration of HF may be a potential preventive therapy for OA.
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November-2017
Volume 16 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Mu W, Xu B, Ma H, Ji B, Zhang Z, Li J, Amat A and Cao L: Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF‑β1 signaling in articular cartilage in a rodent osteoarthritis model. Mol Med Rep 16: 7679-7684, 2017.
APA
Mu, W., Xu, B., Ma, H., Ji, B., Zhang, Z., Li, J. ... Cao, L. (2017). Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF‑β1 signaling in articular cartilage in a rodent osteoarthritis model. Molecular Medicine Reports, 16, 7679-7684. https://doi.org/10.3892/mmr.2017.7549
MLA
Mu, W., Xu, B., Ma, H., Ji, B., Zhang, Z., Li, J., Amat, A., Cao, L."Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF‑β1 signaling in articular cartilage in a rodent osteoarthritis model". Molecular Medicine Reports 16.5 (2017): 7679-7684.
Chicago
Mu, W., Xu, B., Ma, H., Ji, B., Zhang, Z., Li, J., Amat, A., Cao, L."Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF‑β1 signaling in articular cartilage in a rodent osteoarthritis model". Molecular Medicine Reports 16, no. 5 (2017): 7679-7684. https://doi.org/10.3892/mmr.2017.7549