Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells

  • Authors:
    • Green Kim
    • Jae‑Eun Kim
    • Min‑Jung Kang
    • Ah‑Ra Jang
    • Young Ran Kim
    • Sunoh Kim
    • Kyu‑Tae Chang
    • Jung Joo Hong
    • Jong‑Hwan Park
  • View Affiliations

  • Published online on: October 13, 2017     https://doi.org/10.3892/mmr.2017.7793
  • Pages: 9573-9578
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Abstract

Helicobacter pylori (H. pylori) infection activates pro‑inflammatory mediators, including interleukin (IL)‑8 and vascular endothelial growth factor (VEGF) in gastric epithelial cells. 1‑Tetradecanol (1‑TD) has been purified from Dendropanax morbifera Leveille; its physiological activities are poorly understood. The present study assessed whether 1‑TD has an effect on H. pylori‑mediated inflammation in AGS gastric epithelial cells. 1‑TD reduced IL‑8 production by AGS cells in response to H. pylori in a significant and dose‑dependent manner, as measured by ELISA. Western blot analysis demonstrated that 1‑TD also suppressed the activation of nuclear factor‑κB, and two mitogen activated protein kinase species (p38 and extracellular signal‑regulated kinase 1/2), but not c‑Jun N‑terminal kinase in H. pylori‑infected AGS cells. As predicted, VEGF expression and hypoxia inducible factor‑1α stabilization induced by H. pylori in AGS cells were inhibited by 1‑TD. In addition, 1‑TD directly inhibited the growth of H. pylori in a dose‑dependent manner, as investigated by measuring the optical density. These findings indicated that 1‑TD may be a potential preventive or therapeutic agent for H. pylori‑induced gastric inflammation.
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December-2017
Volume 16 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Kim G, Kim JE, Kang MJ, Jang AR, Kim YR, Kim S, Chang KT, Hong JJ and Park JH: Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells. Mol Med Rep 16: 9573-9578, 2017.
APA
Kim, G., Kim, J., Kang, M., Jang, A., Kim, Y.R., Kim, S. ... Park, J. (2017). Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells. Molecular Medicine Reports, 16, 9573-9578. https://doi.org/10.3892/mmr.2017.7793
MLA
Kim, G., Kim, J., Kang, M., Jang, A., Kim, Y. R., Kim, S., Chang, K., Hong, J. J., Park, J."Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells". Molecular Medicine Reports 16.6 (2017): 9573-9578.
Chicago
Kim, G., Kim, J., Kang, M., Jang, A., Kim, Y. R., Kim, S., Chang, K., Hong, J. J., Park, J."Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells". Molecular Medicine Reports 16, no. 6 (2017): 9573-9578. https://doi.org/10.3892/mmr.2017.7793