MicroRNA‑663 suppresses the proliferation and invasion of colorectal cancer cells by directly targeting FSCN1

  • Authors:
    • Shaojun Yu
    • Haiting Xie
    • Jingjing Zhang
    • Da Wang
    • Yongmao Song
    • Suzhan Zhang
    • Shu Zheng
    • Jian Wang
  • View Affiliations

  • Published online on: October 17, 2017     https://doi.org/10.3892/mmr.2017.7794
  • Pages: 9707-9714
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Abstract

Colorectal cancer (CRC) is the most frequently diagnosed malignancy of the gastrointestinal tract. The dysregulation of microRNAs (miRNAs/miRs) has been reported in the majority of types of human cancer, and is correlated with tumorigenesis and tumor development. Abnormal expression of miR‑663 has been observed in various types of human cancer. However, little is known about its role in CRC. Therefore, the aim of the present study was to clarify the expression and potential role of miR‑663, and its underlying molecular mechanism in CRC. It was observed that miR‑663 was markedly downregulated in CRC tissues and cell lines. Decreased miR‑663 expression levels in CRC tissues were correlated with tumor, node, metastasis stage and lymph node metastasis. Functional assays revealed that upregulation of miR‑663 inhibited cell proliferation and invasion in CRC. Further molecular mechanism assays demonstrated the fascin (FSCN1) was a target gene of miR‑663. In addition, FSCN1 was increased and negatively correlated with miR‑663 expression in CRC tissues. FSCN1 underexpression mimicked the tumor suppressive functions induced by miR‑663 overexpression on CRC cell proliferation and invasion. Collectively, the present study presented evidence that miR‑663 may act as a tumor suppressor in CRC by directly targeting FSCN1, which may lead to a potential therapeutic strategy focusing on miR‑663 and FSCN1 for patients with this disease.
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December-2017
Volume 16 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yu S, Xie H, Zhang J, Wang D, Song Y, Zhang S, Zheng S and Wang J: MicroRNA‑663 suppresses the proliferation and invasion of colorectal cancer cells by directly targeting FSCN1. Mol Med Rep 16: 9707-9714, 2017
APA
Yu, S., Xie, H., Zhang, J., Wang, D., Song, Y., Zhang, S. ... Wang, J. (2017). MicroRNA‑663 suppresses the proliferation and invasion of colorectal cancer cells by directly targeting FSCN1. Molecular Medicine Reports, 16, 9707-9714. https://doi.org/10.3892/mmr.2017.7794
MLA
Yu, S., Xie, H., Zhang, J., Wang, D., Song, Y., Zhang, S., Zheng, S., Wang, J."MicroRNA‑663 suppresses the proliferation and invasion of colorectal cancer cells by directly targeting FSCN1". Molecular Medicine Reports 16.6 (2017): 9707-9714.
Chicago
Yu, S., Xie, H., Zhang, J., Wang, D., Song, Y., Zhang, S., Zheng, S., Wang, J."MicroRNA‑663 suppresses the proliferation and invasion of colorectal cancer cells by directly targeting FSCN1". Molecular Medicine Reports 16, no. 6 (2017): 9707-9714. https://doi.org/10.3892/mmr.2017.7794