Open Access

Therapeutic effects of STAT3 inhibition by nifuroxazide on murine acute graft graft-vs.-host disease: Old drug, new use

  • Authors:
    • Huijie Jia
    • Jing Cui
    • Xiaolong Jia
    • Jingjing Zhao
    • Yuchen Feng
    • Peijuan Zhao
    • Dan Zang
    • Jian Yu
    • Tiesuo Zhao
    • Hui Wang
    • Kailin Xu
  • View Affiliations

  • Published online on: October 19, 2017     https://doi.org/10.3892/mmr.2017.7825
  • Pages: 9480-9486
  • Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Graft‑vs.‑host disease (GvHD) is a major and lethal complication of allogeneic bone marrow transplantation (allo‑BMT). Although great development has been made, the treatment progress of this disorder is slow. Research has illustrated that STAT3 was critical for T cell alloactivation in GvHD. In the present study, the authors hypothesized that nifuroxazide, as the STAT3 inhibitor, treatment may attenuate the development of acute GvHD (aGvHD). The results demonstrated that nifuroxazide suppressed the development of aGvHD and significantly delayed aGvHD‑induced lethality. Mice receiving nifuroxazide had mostly normal‑appearing skin with minimal focal ulceration, mild edema and congestion in the liver, and a less‑pronounced villus injury and less inflammatory infiltrate in the small intestine. Treatment with nifuroxazide inhibited the activation of STAT3, resulting in the regulation of the CD4+ T cells and CD4+CD25+ T cells and reduction of interferon‑γ and tumor necrosis factor‑α levels. In conclusion, nifuroxazide may be efficacious for post‑transplant of GvHD, providing a potent drug for use as a prophylactic or as a second‑line therapy for aGvHD in clinical trials.
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December-2017
Volume 16 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Jia H, Cui J, Jia X, Zhao J, Feng Y, Zhao P, Zang D, Yu J, Zhao T, Wang H, Wang H, et al: Therapeutic effects of STAT3 inhibition by nifuroxazide on murine acute graft graft-vs.-host disease: Old drug, new use. Mol Med Rep 16: 9480-9486, 2017.
APA
Jia, H., Cui, J., Jia, X., Zhao, J., Feng, Y., Zhao, P. ... Xu, K. (2017). Therapeutic effects of STAT3 inhibition by nifuroxazide on murine acute graft graft-vs.-host disease: Old drug, new use. Molecular Medicine Reports, 16, 9480-9486. https://doi.org/10.3892/mmr.2017.7825
MLA
Jia, H., Cui, J., Jia, X., Zhao, J., Feng, Y., Zhao, P., Zang, D., Yu, J., Zhao, T., Wang, H., Xu, K."Therapeutic effects of STAT3 inhibition by nifuroxazide on murine acute graft graft-vs.-host disease: Old drug, new use". Molecular Medicine Reports 16.6 (2017): 9480-9486.
Chicago
Jia, H., Cui, J., Jia, X., Zhao, J., Feng, Y., Zhao, P., Zang, D., Yu, J., Zhao, T., Wang, H., Xu, K."Therapeutic effects of STAT3 inhibition by nifuroxazide on murine acute graft graft-vs.-host disease: Old drug, new use". Molecular Medicine Reports 16, no. 6 (2017): 9480-9486. https://doi.org/10.3892/mmr.2017.7825