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Article Open Access

Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis

  • Authors:
    • Yulong Wei
    • Jie Jia
    • Xin Jin
    • Wei Tong
    • Hongtao Tian
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1493-1498
    |
    Published online on: November 13, 2017
       https://doi.org/10.3892/mmr.2017.8036
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Abstract

Resveratrol is a non‑flavonoid polyphenol compound with a stilbene structure. As a type of phytoalexin produced under stress in plants, it improves the plant's resistance against pathogens and environment deterioration, and performs important functions beneficial to human health, such as anti‑cancer, anti‑oxidation, regulating blood lipid levels and prolonging life span. The effects of resveratrol were examined in a rat model of osteoarthritis (OA) and observed to ameliorate inflammatory damage and protect against OA. In the present study, resveratrol significantly inhibited the induction of clinical scores in rats with OA. Resveratrol inhibited tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6 and IL‑18 expression levels, and decreased caspase‑3/9 activity in rats with OA. Inducible nitric oxide synthase, nuclear factor (NF)‑κB, phosphorylated‑(p)‑AMP‑activated protein kinase and sirtuin 1 protein expression were significantly suppressed and heme oxygenase 1 (HO‑1) and nuclear factor erythroid 2‑related factor 2 (Nrf‑2) protein expression was stimulated in rats with OA treated with resveratrol. The current results indicate that resveratrol ameliorates inflammatory damage and protects against OA in a rat model of OA via NF‑κB and HO‑1/Nrf‑2 signaling.
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Copy and paste a formatted citation
Spandidos Publications style
Wei Y, Jia J, Jin X, Tong W and Tian H: Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis. Mol Med Rep 17: 1493-1498, 2018.
APA
Wei, Y., Jia, J., Jin, X., Tong, W., & Tian, H. (2018). Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis. Molecular Medicine Reports, 17, 1493-1498. https://doi.org/10.3892/mmr.2017.8036
MLA
Wei, Y., Jia, J., Jin, X., Tong, W., Tian, H."Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis". Molecular Medicine Reports 17.1 (2018): 1493-1498.
Chicago
Wei, Y., Jia, J., Jin, X., Tong, W., Tian, H."Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis". Molecular Medicine Reports 17, no. 1 (2018): 1493-1498. https://doi.org/10.3892/mmr.2017.8036
Copy and paste a formatted citation
x
Spandidos Publications style
Wei Y, Jia J, Jin X, Tong W and Tian H: Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis. Mol Med Rep 17: 1493-1498, 2018.
APA
Wei, Y., Jia, J., Jin, X., Tong, W., & Tian, H. (2018). Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis. Molecular Medicine Reports, 17, 1493-1498. https://doi.org/10.3892/mmr.2017.8036
MLA
Wei, Y., Jia, J., Jin, X., Tong, W., Tian, H."Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis". Molecular Medicine Reports 17.1 (2018): 1493-1498.
Chicago
Wei, Y., Jia, J., Jin, X., Tong, W., Tian, H."Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis". Molecular Medicine Reports 17, no. 1 (2018): 1493-1498. https://doi.org/10.3892/mmr.2017.8036
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