The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway

  • Authors:
    • Xueqiang Zhu
    • Hui Huang
    • Jun Zhang
    • Hao Liu
    • Rui Ao
    • Ming Xiao
    • Yuelei Wu
  • View Affiliations

  • Published online on: November 22, 2017     https://doi.org/10.3892/mmr.2017.8141
  • Pages: 2750-2756
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Abstract

The present study aimed to identify potential anticancer effects of Cucurbitacin I regulators on cell growth of human non‑small cell lung cancer (NSCLC) and to explore their mechanism. The results indicated that the anticancer effects of Cucurbitacin I markedly attenuated cell proliferation, and induced apoptosis in NSCLC. Furthermore, Cucurbitacin I suppressed phosphatidylinositol‑4,5‑bisphosphate 3‑kinase (PI3K), phosphorylation (p)‑AKT and p‑p70S6K pathway in NSCLC. Then, (PI3K) inhibitor increased anticancer effects of Cucurbitacin I on NSCLC. In conclusion, the present results indicated that Cucurbitacin I inhibited cell growth of human NSCLC through PI3K/AKT/p70S6K signaling pathway.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhu X, Huang H, Zhang J, Liu H, Ao R, Xiao M and Wu Y: The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway. Mol Med Rep 17: 2750-2756, 2018
APA
Zhu, X., Huang, H., Zhang, J., Liu, H., Ao, R., Xiao, M., & Wu, Y. (2018). The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway. Molecular Medicine Reports, 17, 2750-2756. https://doi.org/10.3892/mmr.2017.8141
MLA
Zhu, X., Huang, H., Zhang, J., Liu, H., Ao, R., Xiao, M., Wu, Y."The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway". Molecular Medicine Reports 17.2 (2018): 2750-2756.
Chicago
Zhu, X., Huang, H., Zhang, J., Liu, H., Ao, R., Xiao, M., Wu, Y."The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway". Molecular Medicine Reports 17, no. 2 (2018): 2750-2756. https://doi.org/10.3892/mmr.2017.8141