Open Access

Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism

  • Authors:
    • Ting‑Jun Jiang
    • Xue‑Liang Cao
    • Sha Luan
    • Wan‑Hui Cui
    • Si‑Huang Qiu
    • Yi‑Chao Wang
    • Chang‑Jiu Zhao
    • Peng Fu
  • View Affiliations

  • Published online on: November 27, 2017     https://doi.org/10.3892/mmr.2017.8154
  • Pages: 2137-2144
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The current study observed the percentage of peripheral blood (PB) CD4+CD25+ regulatory T cells (Tregs) and the influence of CD4+CD25+ Tregs on the proliferation of naïve CD4 T cells in patients with hyperthyroidism. Furthermore, preliminary discussions are presented on the action mechanism of CD4+CD25+ Tregs on hyperthyroidism attacks. The present study identified that compared with the percentage of PB CD4+CD25+ Tregs in healthy control subjects, no significant changes were observed in the percentage of PB CD4+CD25+ Tregs in patients with hyperthyroidism (P>0.05). For patients with hyperthyroidism, CD4+CD25+ Tregs exhibited significantly reduced inhibition of the proliferation of naïve CD4 T cells and decreased secretion capacity on the cytokines of CD4 T cells, compared with those of healthy control subjects (P<0.05). In addition, it was demonstrated that thyroid function of patients with hyperthyroidism was significantly improved (P<0.05) subsequent to receiving medication. Compared with the percentage of PB CD4+CD25+ Tregs in patients with hyperthyroidism before treatment, no significant changes were observed in the percentage of PB CD4+CD25+ Tregs in hyperthyroidism patients following treatment (P>0.05). In the patients with hyperthyroidism, following treatment, CD4+CD25+ Tregs exhibited significantly increased inhibition of the proliferation of naïve CD4 T cells and increased secretion capacity of CD4 T cell cytokines, compared with those of the patients with hyperthyroidism prior to treatment (P<0.05). PB CD4+CD25+ Tregs function was decreased in patients with hyperthyroidism, and its non‑proportional decrease may be closely associated with the occurrence and progression of hyperthyroidism.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Jiang TJ, Cao XL, Luan S, Cui WH, Qiu SH, Wang YC, Zhao CJ and Fu P: Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism. Mol Med Rep 17: 2137-2144, 2018.
APA
Jiang, T., Cao, X., Luan, S., Cui, W., Qiu, S., Wang, Y. ... Fu, P. (2018). Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism. Molecular Medicine Reports, 17, 2137-2144. https://doi.org/10.3892/mmr.2017.8154
MLA
Jiang, T., Cao, X., Luan, S., Cui, W., Qiu, S., Wang, Y., Zhao, C., Fu, P."Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism". Molecular Medicine Reports 17.2 (2018): 2137-2144.
Chicago
Jiang, T., Cao, X., Luan, S., Cui, W., Qiu, S., Wang, Y., Zhao, C., Fu, P."Percentage and function of CD4+CD25+ regulatory T cells in patients with hyperthyroidism". Molecular Medicine Reports 17, no. 2 (2018): 2137-2144. https://doi.org/10.3892/mmr.2017.8154