Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells

Ding,Weiji; Zhang,Yunda; Cai,Huali; Liu,Gang; Ye,Yongzhi; Xu,Guoxing; Wang,Haibin; Xiong,Disheng; Zhang,Chuankai; Huang,Zhengjie; Luo,Qi

doi:10.3892/mmr.2017.8164

Overexpression of COUP‑TFII suppresses proliferation and metastasis of human gastric cancer cells

Authors:
- Weiji Ding
- Yunda Zhang
- Huali Cai
- Gang Liu
- Yongzhi Ye
- Guoxing Xu
- Haibin Wang
- Disheng Xiong
- Chuankai Zhang
- Zhengjie Huang
- Qi Luo
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Affiliations: Department of Gastrointestinal Surgery, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China
Published online on: November 27, 2017 https://doi.org/10.3892/mmr.2017.8164
Pages: 2393-2401
Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The abnormal expression of the chicken ovalbumin upstream promoter transcription factor 2 (COUP‑TFII) is associated with numerous forms of cancer, including gastric, prostate, colon and lung cancer. However, previous studies investigating the association between COUP‑TFII expression and the occurrence, recurrence, invasion and metastasis of gastric cancer are limited in number. In the present study, it was revealed that the expression of COUP‑TFII is significantly reduced in gastric carcinoma tissues compared with normal gastric mucosa cells (GES‑1). In addition, the expression of COUP‑TFII was also reduced in gastric cancer cell lines compared with GES‑1 cells. Furthermore, it was revealed that ectopic expression of COUP‑TFII was able to suppress the proliferation, migration and invasion of gastric cells, as well as inhibit hepatic metastasis, in vivo. In addition, it was demonstrated that COUP‑TFII knockdown was able to promote the proliferation, migration and invasion of GES‑1 cells in vitro. Furthermore, database analysis suggested that COUP‑TFII expression in patients with gastric cancer is correlated with clinical stage classification and increased expression levels of COUP‑TFII improved overall survival rates in patients with gastric cancer. The results of the present study suggest that COUP‑TFII functions as a significant regulatory suppressor of gastric cancer growth and metastasis, and suggests that COUP‑TFII may serve as a novel diagnostic and prognostic biomarker for gastric cancer metastasis.

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