Open Access

The spectrum of myocardial homeostasis mechanisms in the settings of cardiac surgery procedures (Review)

  • Authors:
    • Emmanuel Papadakis
    • Meletios Kanakis
    • Agapi Kataki
    • Demetrios A. Spandidos
  • View Affiliations

  • Published online on: November 28, 2017     https://doi.org/10.3892/mmr.2017.8174
  • Pages: 2089-2099
  • Copyright: © Papadakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Classic cardiac surgery, determined through the function of cardiopulmonary bypass machine and myocardial cardioplegic arrest, represents the most controlled scenario for cardiomyocyte homeostatic disturbances due to systemic inflammatory response and myocardial reperfusion injury. An increasing number of studies have demonstrated that myocardial cell homeostasis in cardiac surgery procedures is a sequence of molecularly interrelated and overlapping mechanisms in the form of apoptosis, autophagy and necrosis, which are activated by a plethora of induced inflammatory mediators and gene‑related signaling pathways. In this study, we outline the molecular mechanisms of the cardiomyocyte adaptive homeostatic process and the associated clinical implications, in the settings of classic cardiac surgery procedures.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Papadakis E, Kanakis M, Kataki A and Spandidos DA: The spectrum of myocardial homeostasis mechanisms in the settings of cardiac surgery procedures (Review). Mol Med Rep 17: 2089-2099, 2018
APA
Papadakis, E., Kanakis, M., Kataki, A., & Spandidos, D.A. (2018). The spectrum of myocardial homeostasis mechanisms in the settings of cardiac surgery procedures (Review). Molecular Medicine Reports, 17, 2089-2099. https://doi.org/10.3892/mmr.2017.8174
MLA
Papadakis, E., Kanakis, M., Kataki, A., Spandidos, D. A."The spectrum of myocardial homeostasis mechanisms in the settings of cardiac surgery procedures (Review)". Molecular Medicine Reports 17.2 (2018): 2089-2099.
Chicago
Papadakis, E., Kanakis, M., Kataki, A., Spandidos, D. A."The spectrum of myocardial homeostasis mechanisms in the settings of cardiac surgery procedures (Review)". Molecular Medicine Reports 17, no. 2 (2018): 2089-2099. https://doi.org/10.3892/mmr.2017.8174