Clinical significance of CCBE1 expression in lung cancer

Li,Peng; Cong,Zhuangzhuang; Qiang,Yong; Xiong,Lei; Tang,Li; Zhang,Yu; Wu,Haiwei; Yi,Jun; Jing,Hua; Li,Demin; Shen,Yi

doi:10.3892/mmr.2017.8187

Clinical significance of CCBE1 expression in lung cancer

Authors:
- Peng Li
- Zhuangzhuang Cong
- Yong Qiang
- Lei Xiong
- Li Tang
- Yu Zhang
- Haiwei Wu
- Jun Yi
- Hua Jing
- Demin Li
- Yi Shen
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Affiliations: Department of Cardiothoracic Surgery, Jinling Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Cardiothoracic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, P.R. China, Department of Laboratory Medicine of Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China
Published online on: November 29, 2017 https://doi.org/10.3892/mmr.2017.8187
Pages: 2107-2112
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lymph node metastasis (LNM) is one of the major causes of cancer‑associated morbidity and mortality in patients with lung cancer following radical pulmonary carcinoma resection. The present study aimed to investigate the relationship between the expression of collagen and calcium‑binding epidermal growth factor domain‑containing protein 1 (CCBE1) and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1) in tumor tissue with the clinical prognosis of lung cancer. The present study included 40 patients with lung cancer that underwent pulmonary carcinoma resection, including 10 patients with LNM, and 10 control patients who underwent pulmonary bullae resection. CCBE1 and LYVE1 expression was assessed in samples from normal and tumor tissue using polymerase chain reaction, western blot analysis and immunohistochemistry. CCBE1 expression appeared to be decreased in lung tumor tissue and further downregulated in samples from patients with LNM, and was revealed to be correlated with poor clinical outcome. Conversely, LYVE1 expression appeared to be upregulated in lung cancer tissue. In conclusion, the present results suggested that CCBE1 and LYVE1 may have potential as biomarkers for the identification of lung cancer patients at a high risk of LNM.

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