Open Access

COX‑2 inhibition in the endothelium induces glucose metabolism normalization and impairs tumor progression

  • Authors:
    • Longhui Zhang
    • Sufen Li
    • Lan Li
    • Zhengqiong Chen
    • Ying Yang
  • View Affiliations

  • Published online on: December 12, 2017     https://doi.org/10.3892/mmr.2017.8270
  • Pages: 2937-2944
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Previous antitumor angiogenesis strategies have focused on targeting angiogenic signals. Encouragingly, the metabolism of tumor endothelial cells (TECs) has gained attention as a therapeutic target in recent years. There is consensus that, in terms of antitumor angiogenesis, the promotion of tumor vascular regression and normalization of the remaining blood vessels are equally important. Presently, tumor vessel normalization (TVN) is an emerging antitumor treatment. The present study focused on the normalization of TEC metabolism. The results demonstrated that TECs have a hyperglycolytic metabolism. Parixibox, a cyclooxygenase‑2 (COX‑2) blocker, successively reduces the expression of vascular endothelial growth factor (VEGF) in the tumor microenvironment. VEGF further influences the expression of 6‑Phosphofructo-2-Kinase/Fructose-2,6‑Biphosphatase 3, a key glycolysis gene. Pharmacological blockade of COX‑2 restored the glucose metabolism level (particularly glycolysis) in TECs, which may be an important basic process in TVN. Therefore, COX‑2, which acts on abnormal tumor vessels, is expected to become a novel target for tumor treatment.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang L, Li S, Li L, Chen Z and Yang Y: COX‑2 inhibition in the endothelium induces glucose metabolism normalization and impairs tumor progression. Mol Med Rep 17: 2937-2944, 2018
APA
Zhang, L., Li, S., Li, L., Chen, Z., & Yang, Y. (2018). COX‑2 inhibition in the endothelium induces glucose metabolism normalization and impairs tumor progression. Molecular Medicine Reports, 17, 2937-2944. https://doi.org/10.3892/mmr.2017.8270
MLA
Zhang, L., Li, S., Li, L., Chen, Z., Yang, Y."COX‑2 inhibition in the endothelium induces glucose metabolism normalization and impairs tumor progression". Molecular Medicine Reports 17.2 (2018): 2937-2944.
Chicago
Zhang, L., Li, S., Li, L., Chen, Z., Yang, Y."COX‑2 inhibition in the endothelium induces glucose metabolism normalization and impairs tumor progression". Molecular Medicine Reports 17, no. 2 (2018): 2937-2944. https://doi.org/10.3892/mmr.2017.8270