Open Access

Lin28/microRNA-let-7a promotes metastasis under circumstances of hyperactive Wnt signaling in esophageal squamous cell carcinoma

  • Authors:
    • Rui Ling
    • Yuepeng Zhou
    • Ling Zhou
    • Dongfang Dai
    • Dan Wu
    • Lei Mi
    • Chaoming Mao
    • Deyu Chen
  • View Affiliations

  • Published online on: February 2, 2018     https://doi.org/10.3892/mmr.2018.8548
  • Pages: 5265-5271
  • Copyright: © Ling et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dysregulation of micro (mi)RNA-let-7 has been associated with the development and prognosis of multiple cancer types. Lin28, a RNA-binding protein, plays a conserved role in regulating the maturation of let-7 family proteins. However, few studies have focused on the effects of Lin28/let-7 on Wnt-activated esophageal squamous cell carcinoma (ESCC). Analysis of the expression of let-7a, let-7b and let-7c in clinical tissues revealed that lower let-7a expression was correlated with higher tumor node metastasis staging and recurrence in patients with ESCC. Furthermore, it was demonstrated that let-7a was inversely correlated with the migration and invasion of ESCC cells. In addition, epithelial-mesenchymal transition, and the expression of VEGF-C and MMP9 were effectively decreased by let-7a-mimic or siRNA-Lin28 pretreatment. Mechanistically, Lin28 functioned as the key factor in signal transduction, which regulated the expression of let-7a and the downstream genes along the Wnt signaling pathway. Taken together, these findings identified a biochemical and functional association between Lin28/let-7a, and the Wnt pathway in ESCC cells.
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April-2018
Volume 17 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Ling R, Zhou Y, Zhou L, Dai D, Wu D, Mi L, Mao C and Chen D: Lin28/microRNA-let-7a promotes metastasis under circumstances of hyperactive Wnt signaling in esophageal squamous cell carcinoma. Mol Med Rep 17: 5265-5271, 2018.
APA
Ling, R., Zhou, Y., Zhou, L., Dai, D., Wu, D., Mi, L. ... Chen, D. (2018). Lin28/microRNA-let-7a promotes metastasis under circumstances of hyperactive Wnt signaling in esophageal squamous cell carcinoma. Molecular Medicine Reports, 17, 5265-5271. https://doi.org/10.3892/mmr.2018.8548
MLA
Ling, R., Zhou, Y., Zhou, L., Dai, D., Wu, D., Mi, L., Mao, C., Chen, D."Lin28/microRNA-let-7a promotes metastasis under circumstances of hyperactive Wnt signaling in esophageal squamous cell carcinoma". Molecular Medicine Reports 17.4 (2018): 5265-5271.
Chicago
Ling, R., Zhou, Y., Zhou, L., Dai, D., Wu, D., Mi, L., Mao, C., Chen, D."Lin28/microRNA-let-7a promotes metastasis under circumstances of hyperactive Wnt signaling in esophageal squamous cell carcinoma". Molecular Medicine Reports 17, no. 4 (2018): 5265-5271. https://doi.org/10.3892/mmr.2018.8548