Downregulated CDK10 expression in gastric cancer: Association with tumor progression and poor prognosis

  • Authors:
    • Yanjie You
    • Feihu Bai
    • Zhengcai Ye
    • Nan Zhang
    • Li Yao
    • Yuanyuan Tang
    • Ximei Li
  • View Affiliations

  • Published online on: March 1, 2018     https://doi.org/10.3892/mmr.2018.8662
  • Pages: 6812-6818
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Abstract

The tumor suppressor characteristics of cyclin‑dependent kinase 10 (CDK10) in nasopharyngeal carcinoma and breast cancer have been previously demonstrated. In the present study the expression status of CDK10 and its prognostic significance in gastric cancer was determined, as well as its role in cell proliferation and invasion. Immunoblot analysis revealed that CDK10 protein expression was notably decreased in gastric cancer compared with normal tissues. Immunohistochemistry demonstrated that the loss of CDK10 expression, which was observed in 50.8% of primary gastric cancer tissues (n=128), significantly correlated with advanced tumor stage (P<0.001), frequent lymph node metastasis (P<0.001), distant metastasis (P=0.013), tumor differentiation (P=0.004) and unfavorable overall survival (P<0.001). Multivariate analysis suggested that CDK10 expression may serve as an independent prognostic predictor (P=0.001) for the progression of gastric cancer. In addition, ectopic CDK10 expression inhibited gastric cancer cell proliferation, migration and invasion, while knockdown of CDK10 promoted these phenotypes. Collectively, the results of the present study indicated that CDK10 expression may serve as a novel prognostic biomarker that holds therapeutic promise for gastric cancer.
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May-2018
Volume 17 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
You Y, Bai F, Ye Z, Zhang N, Yao L, Tang Y and Li X: Downregulated CDK10 expression in gastric cancer: Association with tumor progression and poor prognosis. Mol Med Rep 17: 6812-6818, 2018.
APA
You, Y., Bai, F., Ye, Z., Zhang, N., Yao, L., Tang, Y., & Li, X. (2018). Downregulated CDK10 expression in gastric cancer: Association with tumor progression and poor prognosis. Molecular Medicine Reports, 17, 6812-6818. https://doi.org/10.3892/mmr.2018.8662
MLA
You, Y., Bai, F., Ye, Z., Zhang, N., Yao, L., Tang, Y., Li, X."Downregulated CDK10 expression in gastric cancer: Association with tumor progression and poor prognosis". Molecular Medicine Reports 17.5 (2018): 6812-6818.
Chicago
You, Y., Bai, F., Ye, Z., Zhang, N., Yao, L., Tang, Y., Li, X."Downregulated CDK10 expression in gastric cancer: Association with tumor progression and poor prognosis". Molecular Medicine Reports 17, no. 5 (2018): 6812-6818. https://doi.org/10.3892/mmr.2018.8662