Open Access

ML-7 attenuates airway inflammation and remodeling via inhibiting the secretion of Th2 cytokines in mice model of asthma

  • Authors:
    • Chuanjun Huang
    • Zewen Zhang
    • Liuxin Wang
    • Ju Liu
    • Xiaodan Gong
    • Caiqing Zhang
  • View Affiliations

  • Published online on: March 6, 2018     https://doi.org/10.3892/mmr.2018.8683
  • Pages: 6293-6300
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Previous studies have indicated that smooth muscle myosin light chain kinase (MLCK) has a prominent role in the regulation of smooth muscle contraction, which tends to be upregulated in asthma. In recent years, numerous studies have reported that MLCK is intimately connected with the immunoregulatory mechanism of T cells. The imbalance of T helper type 1 cells (Th1)/Th2 constitutes the immune‑associated pathological basis of chronic asthma. Th2‑associated cytokines, including interleukin‑4, ‑5, ‑13, ‑25 and ‑33, are involved in airway inflammation, hyperresponsiveness and remodeling, which leads to a progressive decline in lung function. The purpose of the present study was to verify whether inhibition of bronchial MLCK attenuated the expression Th2‑associated cytokines in asthmatic mice, including the above‑mentioned ones. Female BALB/c mice were used to establish an ovalbumin (OVA)‑induced model of asthma, of which one group was treated with the MLCK inhibitor (5-iodonaphthalene-1-sulfonyl) homopiperazine (ML‑7). The inhibitor of MLCK, ML‑7 attenuated airway inflammation and remodeling by reducing inflammatory cell infiltration and the secretion of Th2 cytokines in mice model of asthma, which may represent a promising therapeutic strategy for asthma.
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May-2018
Volume 17 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Huang C, Zhang Z, Wang L, Liu J, Gong X and Zhang C: ML-7 attenuates airway inflammation and remodeling via inhibiting the secretion of Th2 cytokines in mice model of asthma. Mol Med Rep 17: 6293-6300, 2018
APA
Huang, C., Zhang, Z., Wang, L., Liu, J., Gong, X., & Zhang, C. (2018). ML-7 attenuates airway inflammation and remodeling via inhibiting the secretion of Th2 cytokines in mice model of asthma. Molecular Medicine Reports, 17, 6293-6300. https://doi.org/10.3892/mmr.2018.8683
MLA
Huang, C., Zhang, Z., Wang, L., Liu, J., Gong, X., Zhang, C."ML-7 attenuates airway inflammation and remodeling via inhibiting the secretion of Th2 cytokines in mice model of asthma". Molecular Medicine Reports 17.5 (2018): 6293-6300.
Chicago
Huang, C., Zhang, Z., Wang, L., Liu, J., Gong, X., Zhang, C."ML-7 attenuates airway inflammation and remodeling via inhibiting the secretion of Th2 cytokines in mice model of asthma". Molecular Medicine Reports 17, no. 5 (2018): 6293-6300. https://doi.org/10.3892/mmr.2018.8683