Open Access

Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR

  • Authors:
    • Stavros Sifakis
    • Vasilis P. Androutsopoulos
    • Artemis Pontikaki
    • Alexis Velegrakis
    • George I. Papaioannou
    • Ourania Koukoura
    • Demetrios A. Spandidos
    • Nikos Papantoniou
  • View Affiliations

  • Published online on: March 9, 2018     https://doi.org/10.3892/mmr.2018.8721
  • Pages: 6435-6440
  • Copyright: © Sifakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Fetal growth restriction (FGR) is a gynecological disorder of varying etiology. In the present study, an expression analysis of pregnancy-associated plasma protein A (PAPPA), pregnancy-associated plasma protein A2 (PAPPA2) and placenta-specific-1 (PLAC-1) was conducted in pregnancies with FGR and control pregnancies. Placental tissues were collected from pregnancies with FGR (n=16) and control pregnancies (n=16) and the expression of the genes of interest was examined by qPCR. The mean expression levels of PAPPA and PAPPA2 were significantly lower (P<0.001) in placental tissues from FGR pregnancies compared with tissues from healthy subjects, whereas the opposite pattern was observed for PLAC-1 (P<0.001). PAPPA and PLAC-1 expression in FGR and control subjects correlated with birth weight (P<0.001). The findings suggest a possible pathophysiological link between the development of FGR and the expression of PAPPA, PAPPA2 and PLAC-1.
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May-2018
Volume 17 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Sifakis S, Androutsopoulos VP, Pontikaki A, Velegrakis A, Papaioannou GI, Koukoura O, Spandidos DA and Papantoniou N: Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR. Mol Med Rep 17: 6435-6440, 2018
APA
Sifakis, S., Androutsopoulos, V.P., Pontikaki, A., Velegrakis, A., Papaioannou, G.I., Koukoura, O. ... Papantoniou, N. (2018). Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR. Molecular Medicine Reports, 17, 6435-6440. https://doi.org/10.3892/mmr.2018.8721
MLA
Sifakis, S., Androutsopoulos, V. P., Pontikaki, A., Velegrakis, A., Papaioannou, G. I., Koukoura, O., Spandidos, D. A., Papantoniou, N."Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR". Molecular Medicine Reports 17.5 (2018): 6435-6440.
Chicago
Sifakis, S., Androutsopoulos, V. P., Pontikaki, A., Velegrakis, A., Papaioannou, G. I., Koukoura, O., Spandidos, D. A., Papantoniou, N."Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR". Molecular Medicine Reports 17, no. 5 (2018): 6435-6440. https://doi.org/10.3892/mmr.2018.8721