Placental expression of PAPPA, PAPPA-2 and PLAC-1  in pregnacies is associated with FGR

Sifakis,Stavros; Androutsopoulos,Vasilis  P.; Pontikaki,Artemis; Velegrakis,Alexis; Papaioannou,George   I.; Koukoura,Ourania; Spandidos,Demetrios   A.; Papantoniou,Nikos

doi:10.3892/mmr.2018.8721

Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR

Authors:
- Stavros Sifakis
- Vasilis P. Androutsopoulos
- Artemis Pontikaki
- Alexis Velegrakis
- George I. Papaioannou
- Ourania Koukoura
- Demetrios A. Spandidos
- Nikos Papantoniou
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Affiliations: Department of Obstetrics and Gynecology, University Hospital of Heraklion, 71110 Heraklion, Greece, Department of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece, Department of Obstetrics and Gynecology, Venizeleion Hospital, 71409 Heraklion, Greece, Department of Obstetrics and Gynecology, Attikon University Hospital, University of Athens, 12462 Athens, Greece, Department of Obstetrics and Gynecology, University of Thessalia, 41110 Larissa, Greece, Department of Obstetrics and Gynecology, Attikon University Hospital, University of Athens, 12462 Athens, Greece
Published online on: March 9, 2018 https://doi.org/10.3892/mmr.2018.8721
Pages: 6435-6440
Copyright: © Sifakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Fetal growth restriction (FGR) is a gynecological disorder of varying etiology. In the present study, an expression analysis of pregnancy-associated plasma protein A (PAPPA), pregnancy-associated plasma protein A2 (PAPPA2) and placenta-specific-1 (PLAC-1) was conducted in pregnancies with FGR and control pregnancies. Placental tissues were collected from pregnancies with FGR (n=16) and control pregnancies (n=16) and the expression of the genes of interest was examined by qPCR. The mean expression levels of PAPPA and PAPPA2 were significantly lower (P<0.001) in placental tissues from FGR pregnancies compared with tissues from healthy subjects, whereas the opposite pattern was observed for PLAC-1 (P<0.001). PAPPA and PLAC-1 expression in FGR and control subjects correlated with birth weight (P<0.001). The findings suggest a possible pathophysiological link between the development of FGR and the expression of PAPPA, PAPPA2 and PLAC-1.

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