Open Access

Effects of Bushen-Yizhi formula on age-related inflammation and oxidative stress in senescence-accelerated mice

  • Authors:
    • Xue‑Qin Hou
    • Hou‑Pan Song
    • Yun‑Bo Chen
    • Shu‑Yi Cheng
    • Shu‑Huan Fang
    • Ji‑Guo Zhang
    • Qi Wang
  • View Affiliations

  • Published online on: March 14, 2018     https://doi.org/10.3892/mmr.2018.8736
  • Pages: 6947-6960
  • Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the possible effects and underlying molecular mechanism of Bushen‑Yizhi formula (BSYZ), a traditional Chinese medicine, on age‑related degeneration of brain physiology in senescence‑accelerated mouse prone 8 (SAMP8) mice. SAMP8 mice (age, 6 months) were administered BSYZ (1.46, 2.92 and 5.84 g/kg/day) for 30 days. Morris water maze and step‑down tests demonstrated that BSYZ significantly improved memory impairments in SAMP8 mice. In addition, BSYZ significantly enhanced the expression levels of peroxisome proliferator‑activated receptor‑γ and B‑cell lymphoma extra‑large, and downregulated the expression levels of inflammatory mediators, glial fibrillary acidic protein, cyclooxygenase‑2, nuclear factor‑κB and interleukin‑1β in the brain compared with untreated SAMP8 mice. Furthermore, BSYZ reversed disordered superoxide dismutase activity, malondialdehyde content and glutathione peroxidase activity, and ameliorated apoptosis and histological alterations. The present study indicated that BSYZ may attenuate cognitive impairment in SAMP8 mice, and modulate inflammation, oxidative stress and neuronal apoptosis. These results suggested that BSYZ may have the potential to be further developed into a therapeutic agent for protection against age‑related neurodegenerative diseases.
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May-2018
Volume 17 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Hou XQ, Song HP, Chen YB, Cheng SY, Fang SH, Zhang JG and Wang Q: Effects of Bushen-Yizhi formula on age-related inflammation and oxidative stress in senescence-accelerated mice. Mol Med Rep 17: 6947-6960, 2018
APA
Hou, X., Song, H., Chen, Y., Cheng, S., Fang, S., Zhang, J., & Wang, Q. (2018). Effects of Bushen-Yizhi formula on age-related inflammation and oxidative stress in senescence-accelerated mice. Molecular Medicine Reports, 17, 6947-6960. https://doi.org/10.3892/mmr.2018.8736
MLA
Hou, X., Song, H., Chen, Y., Cheng, S., Fang, S., Zhang, J., Wang, Q."Effects of Bushen-Yizhi formula on age-related inflammation and oxidative stress in senescence-accelerated mice". Molecular Medicine Reports 17.5 (2018): 6947-6960.
Chicago
Hou, X., Song, H., Chen, Y., Cheng, S., Fang, S., Zhang, J., Wang, Q."Effects of Bushen-Yizhi formula on age-related inflammation and oxidative stress in senescence-accelerated mice". Molecular Medicine Reports 17, no. 5 (2018): 6947-6960. https://doi.org/10.3892/mmr.2018.8736