Differential modulation by vanadium pentoxide of the secretion of CXCL8 and CXCL11 chemokines in thyroid cells

  • Authors:
    • Poupak Fallahi
    • Rudy Foddis
    • Giusy Elia
    • Francesca Ragusa
    • Armando Patrizio
    • Giada Frenzilli
    • Salvatore Benvenga
    • Alfonso Cristaudo
    • Alessandro Antonelli
    • Silvia Martina Ferrari
  • View Affiliations

  • Published online on: March 16, 2018     https://doi.org/10.3892/mmr.2018.8764
  • Pages: 7415-7420
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Abstract

Recently it has been hypothesized that vanadium serves a carcinogenic role in the thyroid. However, to date, no in vivo or in vitro studies have evaluated thyroid disruption in humans and/or animals following exposure to vanadium. The present study evaluated the effect of vanadium pentoxide (V2O5) on cell viability and proliferation, and chemokine (C‑X‑C motif) ligand (CXCL)8 and CXCL11 secretion in normal thyrocytes. The results demonstrated that V2O5 had no effect on thyroid follicular cell viability and proliferation. However, V2O5 was able to induce the secretion of CXCL8 and CXCL11 chemokines from thyrocytes. Notably, V2O5 synergistically increased the effect of the interferon (IFN)‑γ on CXCL11 secretion. In addition, V2O5 synergistically increased the effect of tumor necrosis factor‑α on CXCL8 secretion, and abolished the inhibitory effect of IFN‑γ. Overall this induction of CXCL8 and CXCL11 secretion may lead to the induction and perpetuation of an inflammatory reaction in the thyroid. Further studies are now required to evaluate thyroid function and nodule development in subjects who are occupationally exposed, or living in polluted areas.
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May-2018
Volume 17 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Fallahi P, Foddis R, Elia G, Ragusa F, Patrizio A, Frenzilli G, Benvenga S, Cristaudo A, Antonelli A, Ferrari SM, Ferrari SM, et al: Differential modulation by vanadium pentoxide of the secretion of CXCL8 and CXCL11 chemokines in thyroid cells. Mol Med Rep 17: 7415-7420, 2018
APA
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Frenzilli, G. ... Ferrari, S.M. (2018). Differential modulation by vanadium pentoxide of the secretion of CXCL8 and CXCL11 chemokines in thyroid cells. Molecular Medicine Reports, 17, 7415-7420. https://doi.org/10.3892/mmr.2018.8764
MLA
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Frenzilli, G., Benvenga, S., Cristaudo, A., Antonelli, A., Ferrari, S. M."Differential modulation by vanadium pentoxide of the secretion of CXCL8 and CXCL11 chemokines in thyroid cells". Molecular Medicine Reports 17.5 (2018): 7415-7420.
Chicago
Fallahi, P., Foddis, R., Elia, G., Ragusa, F., Patrizio, A., Frenzilli, G., Benvenga, S., Cristaudo, A., Antonelli, A., Ferrari, S. M."Differential modulation by vanadium pentoxide of the secretion of CXCL8 and CXCL11 chemokines in thyroid cells". Molecular Medicine Reports 17, no. 5 (2018): 7415-7420. https://doi.org/10.3892/mmr.2018.8764