Open Access

Androgen receptor‑mediated upregulation of quaking affects androgen receptor‑related prostate cancer development and anti‑androgen receptor therapy

  • Authors:
    • Keke Zhang
    • Fei Yan
    • Xiaoying Lei
    • Di Wei
    • Huanyu Lu
    • Zheng Zhu
    • An Xiang
    • Zichen Ye
    • Li Wang
    • Wanxiang Zheng
    • Xi'an Li
    • Jiarui Yuan
    • Zifan Lu
    • Jianlin Yuan
  • View Affiliations

  • Published online on: April 13, 2018     https://doi.org/10.3892/mmr.2018.8882
  • Pages: 8203-8211
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The androgen receptor (AR) has a crucial role in prostate cancer. RNA‑binding protein‑mediated post‑transcriptional regulation is important in the initiation and development of cancer. The present study attempted to elucidate the mutual association of AR and RNA‑binding protein quaking (QKI) in the development of prostate cancer. Dual‑luciferase reporter demonstrated that AR can positively regulate the expression of QKI in prostate cancer cell lines due to its effective transcription regulating function. In addition, QKI may increase expression of AR by heat shock protein 90, which is a coactivator of AR, and silencing QKI can increase the sensitive of Casodex, which is an antagonist of AR in castration‑resistant prostate cancer. This may be a new strategy for advanced prostate cancer.
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June-2018
Volume 17 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang K, Yan F, Lei X, Wei D, Lu H, Zhu Z, Xiang A, Ye Z, Wang L, Zheng W, Zheng W, et al: Androgen receptor‑mediated upregulation of quaking affects androgen receptor‑related prostate cancer development and anti‑androgen receptor therapy. Mol Med Rep 17: 8203-8211, 2018.
APA
Zhang, K., Yan, F., Lei, X., Wei, D., Lu, H., Zhu, Z. ... Yuan, J. (2018). Androgen receptor‑mediated upregulation of quaking affects androgen receptor‑related prostate cancer development and anti‑androgen receptor therapy. Molecular Medicine Reports, 17, 8203-8211. https://doi.org/10.3892/mmr.2018.8882
MLA
Zhang, K., Yan, F., Lei, X., Wei, D., Lu, H., Zhu, Z., Xiang, A., Ye, Z., Wang, L., Zheng, W., Li, X., Yuan, J., Lu, Z., Yuan, J."Androgen receptor‑mediated upregulation of quaking affects androgen receptor‑related prostate cancer development and anti‑androgen receptor therapy". Molecular Medicine Reports 17.6 (2018): 8203-8211.
Chicago
Zhang, K., Yan, F., Lei, X., Wei, D., Lu, H., Zhu, Z., Xiang, A., Ye, Z., Wang, L., Zheng, W., Li, X., Yuan, J., Lu, Z., Yuan, J."Androgen receptor‑mediated upregulation of quaking affects androgen receptor‑related prostate cancer development and anti‑androgen receptor therapy". Molecular Medicine Reports 17, no. 6 (2018): 8203-8211. https://doi.org/10.3892/mmr.2018.8882