Knockdown of zinc transporter ZIP8 expression inhibits neuroblastoma progression and metastasis in vitro

  • Authors:
    • Zhengrong Mei
    • Pengke Yan
    • Ying Wang
    • Shaozhi Liu
    • Fang He
  • View Affiliations

  • Published online on: May 2, 2018     https://doi.org/10.3892/mmr.2018.8944
  • Pages: 477-485
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Abstract

Neuroblastoma is one of the leading causes of cancer‑associated mortality worldwide, particularly in children, partially due to the absence of effective therapeutic targets and diagnostic biomarkers. Therefore, novel molecular targets are critical to the development of therapeutic approaches for neuroblastoma. In the present study, the functions of zinc transporter ZIP8 (Zip8), a member of the zinc transporting protein family, were investigated as novel molecular targets in neuroblastoma cancer cells. The proliferation rates of neuroblastoma cancer cells were significantly decreased when Zip8 was knocked down by lentiviral‑mediated RNA interference. Study of the molecular mechanism suggested that Zip8 modulated the expression of key genes involved in the nuclear factor‑κB signaling pathway. Furthermore, Zip8 depletion suppressed the migratory potential of neuroblastoma cancer cells by reducing the expression levels of matrix metalloproteinases. In conclusion, the results of the present study suggested that Zip8 was an important regulator of neuroblastoma cell proliferation and migration, indicating that Zip8 may be a potential anticancer therapeutic target and a promising diagnostic biomarker for human neuroblastoma.
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July-2018
Volume 18 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Mei Z, Yan P, Wang Y, Liu S and He F: Knockdown of zinc transporter ZIP8 expression inhibits neuroblastoma progression and metastasis in vitro. Mol Med Rep 18: 477-485, 2018
APA
Mei, Z., Yan, P., Wang, Y., Liu, S., & He, F. (2018). Knockdown of zinc transporter ZIP8 expression inhibits neuroblastoma progression and metastasis in vitro. Molecular Medicine Reports, 18, 477-485. https://doi.org/10.3892/mmr.2018.8944
MLA
Mei, Z., Yan, P., Wang, Y., Liu, S., He, F."Knockdown of zinc transporter ZIP8 expression inhibits neuroblastoma progression and metastasis in vitro". Molecular Medicine Reports 18.1 (2018): 477-485.
Chicago
Mei, Z., Yan, P., Wang, Y., Liu, S., He, F."Knockdown of zinc transporter ZIP8 expression inhibits neuroblastoma progression and metastasis in vitro". Molecular Medicine Reports 18, no. 1 (2018): 477-485. https://doi.org/10.3892/mmr.2018.8944