Sevoflurane suppresses proliferation by upregulating microRNA-203 in breast cancer cells

Liu,Jiaying; Yang,Longqiu; Guo,Xia; Jin,Guangli; Wang,Qimin; Lv,Dongdong; Liu,Junli; Chen,Qiu; Song,Qiong; Li,Baolin

doi:10.3892/mmr.2018.8949

Sevoflurane suppresses proliferation by upregulating microRNA-203 in breast cancer cells

Authors:
- Jiaying Liu
- Longqiu Yang
- Xia Guo
- Guangli Jin
- Qimin Wang
- Dongdong Lv
- Junli Liu
- Qiu Chen
- Qiong Song
- Baolin Li
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Affiliations: Department of Anesthesiology, The Second Clinical College of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China, Department of Anesthesiology, Huangshi Central Hospital, Huangshi, Hubei 435000, P.R. China, Department of Ophthalmology, Third People's Hospital of Jinan, Jinan, Shandong 250100, P.R. China, Department of Anesthesiology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, P.R. China, Department of Anesthesiology, The Second Clinical College of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China
Published online on: May 3, 2018 https://doi.org/10.3892/mmr.2018.8949
Pages: 455-460

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Abstract

Rapid proliferation is one of the critical characteristics of breast cancer. However, the underlying regulatory mechanism of breast cancer cell proliferation is largely unclear. The present study indicated that sevoflurane, one of inhalational anesthetics, could significantly suppress breast cancer cell proliferation by arresting cell cycle at G1 phase. Notably, the rescue experiment indicated that miR-203 was upregulated by sevoflurane and mediated the function of sevoflurane on suppressing the breast cancer cell proliferation. The present study indicated the function of the sevoflurane/miR-203 signaling pathway on regulating breast cancer cell proliferation. These results provide mechanistic insight into how the sevoflurane/miR-203 signaling pathway supresses proliferation of breast cancer cells, suggesting the sevoflurane/miR-203 pathway may be a potential target in the treatment of breast cancer.

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