Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression

Wang,Dawei; Lou,Xiaoqian; Jiang,Xiao‑Ming; Yang,Chenxi; Liu,Xiao‑Liang; Zhang,Nan

doi:10.3892/mmr.2018.8994

Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression

Authors:
- Dawei Wang
- Xiaoqian Lou
- Xiao‑Ming Jiang
- Chenxi Yang
- Xiao‑Liang Liu
- Nan Zhang
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Affiliations: Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Endocrinology, Second Department, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Centre for Heart and Lung Innovation, University of British Columbia, Vancouver, BC V6P 2G9, Canada
Published online on: May 8, 2018 https://doi.org/10.3892/mmr.2018.8994
Pages: 610-616

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Abstract

With extensive pharmacological actions, quercetin has anti‑oxidant, free radical scavenging, anti‑tumor, anti‑inflammatory, anti‑bacterial and anti‑viral activity. Quercetin also reduces blood glucose and reduces high blood pressure, and has immunoregulation and cardiovascular protection functions. Additionally, it has been reported that it can reduce depression. The current study evaluated whether quercetin protects against inflammation, matrix metalloproteinase‑2 (MMP‑2) activation and apoptosis induction in a rat model of cardiopulmonary resuscitation (CPR), and whether Bmi‑1 expression was involved in the effects. In CPR model rats, treatment with quercetin significantly recovered left ventricular ejection fraction, left ventricular fractional shortening, ejection fraction (%), and left ventricle weight/body weight. Treatment with quercetin significantly inhibited ROS generation, inflammation and MMP‑2 protein expression in the rat model CPR. Finally, quercetin significantly suppressed caspase‑3 activity and activated Bmi‑1 protein expression in the rat model of CPR. The results demonstrated that quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in a rat model of CPR, and that this may be mediated by modulating Bmi‑1 expression.

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