Open Access

Human HLA‑F adjacent transcript 10 promotes the formation of cancer initiating cells and cisplatin resistance in bladder cancer

Retraction in: /10.3892/mmr.2024.13187

  • Authors:
    • Chen Li
    • Zhenfan Wang
    • Ninghan Feng
    • Jian Dong
    • Xiaoyan Deng
    • Yin Yue
    • Yuehong Guo
    • Jianquan Hou
  • View Affiliations

  • Published online on: May 9, 2018     https://doi.org/10.3892/mmr.2018.9005
  • Pages: 308-314
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epithelial to mesenchymal transition (EMT) serves important roles in tumor invasion, metastasis, formation of cancer initiating cells (CICs) and drug resistance. HLA‑F adjacent transcript 10 (FAT10) has been proposed as an oncogene in bladder cancer. However, the functional contribution of FAT10 to EMT and the formation of CICs remains unclear in bladder cancer. The present study reports that FAT10 protein expression is upregulated in bladder cancer cell lines, and the overexpression of FAT10 promotes EMT and the formation of CICs in bladder cancer UMUC‑3 cells. In addition, increased expression of FAT10 in tumor tissue was associated with shorter overall survival and progression free survival in Chinese patients with bladder cancer. Overexpression of FAT10 promotes cisplatin‑resistant bladder cancer formation. These results indicated FAT10 may be a novel target for the treatment of bladder cancer.
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July-2018
Volume 18 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Li C, Wang Z, Feng N, Dong J, Deng X, Yue Y, Guo Y and Hou J: Human HLA‑F adjacent transcript 10 promotes the formation of cancer initiating cells and cisplatin resistance in bladder cancer Retraction in /10.3892/mmr.2024.13187. Mol Med Rep 18: 308-314, 2018
APA
Li, C., Wang, Z., Feng, N., Dong, J., Deng, X., Yue, Y. ... Hou, J. (2018). Human HLA‑F adjacent transcript 10 promotes the formation of cancer initiating cells and cisplatin resistance in bladder cancer Retraction in /10.3892/mmr.2024.13187. Molecular Medicine Reports, 18, 308-314. https://doi.org/10.3892/mmr.2018.9005
MLA
Li, C., Wang, Z., Feng, N., Dong, J., Deng, X., Yue, Y., Guo, Y., Hou, J."Human HLA‑F adjacent transcript 10 promotes the formation of cancer initiating cells and cisplatin resistance in bladder cancer Retraction in /10.3892/mmr.2024.13187". Molecular Medicine Reports 18.1 (2018): 308-314.
Chicago
Li, C., Wang, Z., Feng, N., Dong, J., Deng, X., Yue, Y., Guo, Y., Hou, J."Human HLA‑F adjacent transcript 10 promotes the formation of cancer initiating cells and cisplatin resistance in bladder cancer Retraction in /10.3892/mmr.2024.13187". Molecular Medicine Reports 18, no. 1 (2018): 308-314. https://doi.org/10.3892/mmr.2018.9005