Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family

Abdallah,Qasem; Al‑Deeb,Ibrahim; Bader,Ammar; Hamam,Fayez; Saleh,Kamel; Abdulmajid,Amin

doi:10.3892/mmr.2018.9155

Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family

Authors:
- Qasem Abdallah
- Ibrahim Al‑Deeb
- Ammar Bader
- Fayez Hamam
- Kamel Saleh
- Amin Abdulmajid
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Affiliations: Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, Taif, Makkah 21974, Saudi Arabia, Department of Pharmacology, School of Pharmaceutical Sciences, University Sains Malaysia, Minden, Penang 11800, Malaysia, Department of Pharmacognosy, College of Pharmacy, Umm Al‑Qura University, Makkah 21955, Saudi Arabia, Department of Biology, Science College, King Khalid University, Abha, Asir 61413, Saudi Arabia
Published online on: June 12, 2018 https://doi.org/10.3892/mmr.2018.9155
Pages: 2441-2448
Copyright: © Abdallah et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Angiogenesis plays a crucial role in malignant tumor progression and development. The present study aimed to identify lead plants with selective anti-angiogenic properties. A total of 26 methanolic extracts obtained from 18 plants growing in Saudi Arabia and Jordan that belong to the Lamiaceae family were screened for their cytotoxic and anti-angiogenic activities using MTT and rat aortic ring assays, respectively. Four novel extracts of Thymbra capitata (L.) Cav., Phlomis viscosa Poir, Salvia samuelssonii Rech.f., and Premna resinosa (Hochst.) Schauer were identified for their selective anti-angiogenic effects. These extracts did not exhibit cytotoxic effects on human endothelial cells (EA.hy926) indicating the involvement of indirect anti-angiogenic mechanisms. The active extracts are potential candidates for further phytochemical and mechanistic studies.

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