Open Access

PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review)

  • Authors:
    • Zhen Zhang
    • Li Yao
    • Jinhua Yang
    • Zhenkang Wang
    • Gang Du
  • View Affiliations

  • Published online on: August 9, 2018     https://doi.org/10.3892/mmr.2018.9375
  • Pages: 3547-3554
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hypoxia‑ischemia (H‑I) is frequently observed in perinatal asphyxia and other diseases. It can lead to serious cardiac injury, cerebral damage, neurological disability and mortality. Previous studies have demonstrated that the phosphatidylinositol‑3 kinase (PI3K)/protein kinase B (Akt) signaling pathway, which regulates a wide range of cellular functions, is involved in the resistance response to H‑I through the activation of proteins associated with survival and inactivation of apoptosis‑associated proteins. It can also regulate the expression of hypoxia‑induced factor‑1α (HIF‑1α). HIF‑1α can further regulate the expression of downstream proteins involved in glucose metabolism and angiogenesis, such as vascular endothelial growth factor and erythropoietin, to facilitate ischemic adaptation. Notably, HIF‑1α may also induce detrimental effects. The effects of HIF‑1 on ischemic outcomes may be dependent on the H‑I duration, animal age and species. Thus, further investigation of the PI3K/Akt signaling pathway may provide further insights of the potential targets for treating diseases accompanied by H‑I.
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October-2018
Volume 18 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Z, Yao L, Yang J, Wang Z and Du G: PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review). Mol Med Rep 18: 3547-3554, 2018.
APA
Zhang, Z., Yao, L., Yang, J., Wang, Z., & Du, G. (2018). PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review). Molecular Medicine Reports, 18, 3547-3554. https://doi.org/10.3892/mmr.2018.9375
MLA
Zhang, Z., Yao, L., Yang, J., Wang, Z., Du, G."PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review)". Molecular Medicine Reports 18.4 (2018): 3547-3554.
Chicago
Zhang, Z., Yao, L., Yang, J., Wang, Z., Du, G."PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review)". Molecular Medicine Reports 18, no. 4 (2018): 3547-3554. https://doi.org/10.3892/mmr.2018.9375