1
|
Perz JF, Armstrong GL, Farrington LA,
Hutin YJ and Bell BP: The contributions of hepatitis B virus and
hepatitis C virus infections to cirrhosis and primary liver cancer
worldwide. J Hepatol. 45:529–538. 2006. View Article : Google Scholar : PubMed/NCBI
|
2
|
Schweitzer A, Horn J, Mikolajczyk RT,
Krause G and Ott JJ: Estimations of worldwide prevalence of chronic
hepatitis B virus infection: A systematic review of data published
between 1965 and 2013. Lancet. 386:1546–1555. 2015. View Article : Google Scholar : PubMed/NCBI
|
3
|
Lok AS: Chronic hepatitis B. N Engl J Med.
346:1682–1683. 2002. View Article : Google Scholar : PubMed/NCBI
|
4
|
Chisari FV, Isogawa M and Wieland SF:
Pathogenesis of hepatitis B virus infection. Pathol Biol (Paris).
58:258–266. 2010. View Article : Google Scholar : PubMed/NCBI
|
5
|
Bertoletti A and Ferrari C: Innate and
adaptive immune responses in chronic hepatitis B virus infections:
Towards restoration of immune control of viral infection. Postgrad
Med J. 89:294–304. 2013. View Article : Google Scholar : PubMed/NCBI
|
6
|
Bertoletti A and Gehring AJ: The immune
response during hepatitis B virus infection. J Gen Virol.
87:1439–1449. 2006. View Article : Google Scholar : PubMed/NCBI
|
7
|
Loggi E, Gamal N, Bihl F, Bernardi M and
Andreone P: Adaptive response in hepatitis B virus infection. J
Viral Hepat. 21:305–313. 2014. View Article : Google Scholar : PubMed/NCBI
|
8
|
Asabe S, Wieland SF, Chattopadhyay PK,
Roederer M, Engle RE, Purcell RH and Chisari FV: The size of the
viral inoculum contributes to the outcome of hepatitis B virus
infection. J Virol. 83:9652–9662. 2009. View Article : Google Scholar : PubMed/NCBI
|
9
|
Steinman RM and Hemmi H: Dendritic cells:
Translating innate to adaptive immunity. Curr Top Microbiol
Immunol. 311:17–58. 2006.PubMed/NCBI
|
10
|
Santodonato L, D'Agostino G, Nisini R,
Mariotti S, Monque DM, Spada M, Lattanzi L, Perrone MP, Andreotti
M, Belardelli F and Ferrantini M: Monocyte-derived dendritic cells
generated after a short-term culture with IFN-alpha and
granulocyte-macrophage colony-stimulating factor stimulate a potent
Epstein-Barr virus-specific CD8+ T cell response. J Immunol.
170:5195–5202. 2003. View Article : Google Scholar : PubMed/NCBI
|
11
|
Fonteneau JF, Larsson M, Somersan S,
Sanders C, Münz C, Kwok WW, Bhardwaj N and Jotereau F: Generation
of high quantities of viral and tumor-specific human CD4+ and CD8+
T-cell clones using peptide pulsed mature dendritic cells. J
Immunol Methods. 258:111–126. 2001. View Article : Google Scholar : PubMed/NCBI
|
12
|
Boudreau JE, Bonehill A, Thielemans K and
Wan Y: Engineering dendritic cells to enhance cancer immunotherapy.
Mol Ther. 19:841–853. 2011. View Article : Google Scholar : PubMed/NCBI
|
13
|
Akbar SM, Yoshida O, Chen S, Cesar AJ, Abe
M, Matsuura B, Hiasa Y and Onji M: Immune modulator and antiviral
potential of dendritic cells pulsed with both hepatitis B surface
antigen and core antigen for treating chronic HBV infection.
Antivir Ther. 15:887–895. 2010. View
Article : Google Scholar : PubMed/NCBI
|
14
|
Akbar SM, Chen S, Al-Mahtab M, Abe M,
Hiasa Y and Onji M: Strong and multi-antigen specific immunity by
hepatitis B core antigen (HBcAg)-based vaccines in a murine model
of chronic hepatitis B: HBcAg is a candidate for a therapeutic
vaccine against hepatitis B virus. Antiviral Res. 96:59–64. 2012.
View Article : Google Scholar : PubMed/NCBI
|
15
|
Gao G and Luo H: The ubiquitin-proteasome
pathway in viral infections. Can J Physiol Pharmacol. 84:5–14.
2006. View
Article : Google Scholar : PubMed/NCBI
|
16
|
Chen JH, Yu YS, Chen XH, Liu HH, Zang GQ
and Tang ZH: Enhancement of CTLs induced by DCs loaded with
ubiquitinated hepatitis B virus core antigen. World J
Gastroenterol. 18:1319–1327. 2012. View Article : Google Scholar : PubMed/NCBI
|
17
|
Dai S, Zhuo M, Song L, Chen X, Yu Y, Zang
G and Tang Z: Lentiviral vector encoding ubiquitinated hepatitis B
core antigen induces potent cellular immune responses and
therapeutic immunity in HBV transgenic mice. Immunobiology.
221:813–821. 2016. View Article : Google Scholar : PubMed/NCBI
|
18
|
Chen A, Wang L, Zhang J, Zou L, Jia Z,
Zhou W, Wan Y and Wu Y: H-2 Kd-restricted hepatitis B virus-derived
epitope whose specific CD8+ T lymphocytes can produce gamma
interferon without cytotoxicity. J Virol. 79:5568–5576. 2005.
View Article : Google Scholar : PubMed/NCBI
|
19
|
Dai S, Zhuo M, Song L, Chen X, Yu Y, Tang
Z and Zang G: Dendritic cell-based vaccination with lentiviral
vectors encoding ubiquitinated hepatitis B core antigen enhances
hepatitis B virus-specific immune responses in vivo. Acta Biochim
Biophys Sin (Shanghai). 47:870–879. 2015. View Article : Google Scholar : PubMed/NCBI
|
20
|
Chen X, Tang Y, Zhang Y, Zhuo M, Tang Z,
Yu Y and Zang G: Tapasin modification on the intracellular epitope
HBcAg18-27 enhances HBV-specific CTL immune response and inhibits
hepatitis B virus replication in vivo. Lab Invest. 94:478–490.
2014. View Article : Google Scholar : PubMed/NCBI
|
21
|
Chen X, Liu H, Tang Z, Yu Y and Zang G:
The modification of Tapasin enhances cytotoxic T lymphocyte
activity of intracellularly delivered CTL epitopes via cytoplasmic
transduction peptide. Acta Biochim Biophys Sin (Shanghai).
45:203–212. 2013. View Article : Google Scholar : PubMed/NCBI
|
22
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
23
|
Huang Y, Chen Z, Jia H, Wu W, Zhong S and
Zhou C: Induction of Tc1 response and enhanced cytotoxic T
lymphocyte activity in mice by dendritic cells transduced with
adenovirus expressing HBsAg. Clin Immunol. 119:280–290. 2006.
View Article : Google Scholar : PubMed/NCBI
|
24
|
Bertoletti A, Ferrari C, Fiaccadori F,
Penna A, Margolskee R, Schlicht HJ, Fowler P, Guilhot S and Chisari
FV: HLA class I-restricted human cytotoxic T cells recognize
endogenously synthesized hepatitis B virus nucleocapsid antigen.
Proc Natl Acad Sci USA. 88:10445–10449. 1991. View Article : Google Scholar : PubMed/NCBI
|
25
|
Rehermann B, Fowler P, Sidney J, Person J,
Redeker A, Brown M, Moss B, Sette A and Chisari FV: The cytotoxic T
lymphocyte response to multiple hepatitis B virus polymerase
epitopes during and after acute viral hepatitis. J Exp Med.
181:1047–1058. 1995. View Article : Google Scholar : PubMed/NCBI
|
26
|
Bertoletti A and Ferrari C: Innate and
adaptive immune responses in chronic hepatitis B virus infections:
Towards restoration of immune control of viral infection. Gut.
61:1754–1764. 2012. View Article : Google Scholar : PubMed/NCBI
|
27
|
Das A, Hoare M, Davies N, Lopes AR, Dunn
C, Kennedy PT, Alexander G, Finney H, Lawson A, Plunkett FJ, et al:
Functional skewing of the global CD8 T cell population in chronic
hepatitis B virus infection. J Exp Med. 205:2111–2124. 2008.
View Article : Google Scholar : PubMed/NCBI
|
28
|
Lopes AR, Kellam P, Das A, Dunn C, Kwan A,
Turner J, Peppa D, Gilson RJ, Gehring A, Bertoletti A and Maini MK:
Bim-mediated deletion of antigen-specific CD8 T cells in patients
unable to control HBV infection. J Clin Invest. 118:1835–1845.
2008. View
Article : Google Scholar : PubMed/NCBI
|
29
|
Maini MK and Schurich A: The molecular
basis of the failed immune response in chronic HBV: Therapeutic
implications. J Hepatol. 52:616–619. 2010. View Article : Google Scholar : PubMed/NCBI
|
30
|
Wu L and KewalRamani VN: Dendritic-cell
interactions with HIV: Infection and viral dissemination. Nat Rev
Immunol. 6:859–868. 2006. View
Article : Google Scholar : PubMed/NCBI
|
31
|
Farag MM, Hoyler B, Encke J, Stremmel W
and Weigand K: Dendritic cells can effectively be pulsed by HBVsvp
and induce specific immune reactions in mice. Vaccine. 29:200–206.
2010. View Article : Google Scholar : PubMed/NCBI
|
32
|
Hu B, Tai A and Wang P: Immunization
delivered by lentiviral vectors for cancer and infectious diseases.
Immunol Rev. 239:45–61. 2011. View Article : Google Scholar : PubMed/NCBI
|
33
|
Tavakoli S, Mederacke I, Herzog-Hauff S,
Glebe D, Grün S, Strand D, Urban S, Gehring A, Galle PR and Böcher
WO: Peripheral blood dendritic cells are phenotypically and
functionally intact in chronic hepatitis B virus (HBV) infection.
Clin Exp Immunol. 151:61–70. 2008. View Article : Google Scholar : PubMed/NCBI
|
34
|
Akbar SM, Horiike N and Onji M: Immune
therapy including dendritic cell based therapy in chronic hepatitis
B virus infection. World J Gastroenterol. 12:2876–2883. 2006.
View Article : Google Scholar : PubMed/NCBI
|
35
|
Op den Brouw ML, Binda RS, van Roosmalen
MH, Protzer U, Janssen HL, van der Molen RG and Woltman AM:
Hepatitis B virus surface antigen impairs myeloid dendritic cell
function: A possible immune escape mechanism of hepatitis B virus.
Immunology. 126:280–289. 2009. View Article : Google Scholar : PubMed/NCBI
|
36
|
Phillips S, Chokshi S, Riva A, Evans A,
Williams R and Naoumov NV: CD8 (+) T cell control of hepatitis B
virus replication: Direct comparison between cytolytic and
noncytolytic functions. J Immunol. 184:287–295. 2010. View Article : Google Scholar : PubMed/NCBI
|
37
|
Tsai SL, Sheen IS, Chien RN, Chu CM, Huang
HC, Chuang YL, Lee TH, Liao SK, Lin CL, Kuo GC and Liaw YF:
Activation of Th1 immunity is a common immune mechanism for the
successful treatment of hepatitis B and C: Tetramer assay and
therapeutic implications. J Biomed Sci. 10:120–135. 2003.
View Article : Google Scholar : PubMed/NCBI
|
38
|
Boni C, Bertoletti A, Penna A, Cavalli A,
Pilli M, Urbani S, Scognamiglio P, Boehme R, Panebianco R,
Fiaccadori F and Ferrari C: Lamivudine treatment can restore T cell
responsiveness in chronic hepatitis B. J Clin Invest. 102:968–975.
1998. View Article : Google Scholar : PubMed/NCBI
|
39
|
Rincon M, Conze D, Weiss L, Diehl NL,
Fortner KA, Yang D, Flavell RA, Enslen H, Whitmarsh A and Davis RJ:
Conference highlight: do T cells care about the mitogen-activated
protein kinase signalling pathways? Immunol Cell Biol. 78:166–175.
2000. View Article : Google Scholar : PubMed/NCBI
|
40
|
Yang DD, Conze D, Whitmarsh AJ, Barrett T,
Davis RJ, Rincón M and Flavell RA: Differentiation of CD4+ T cells
to Th1 cells requires MAP kinase JNK2. Immunity. 9:575–585. 1998.
View Article : Google Scholar : PubMed/NCBI
|
41
|
Plotnikov A, Zehorai E, Procaccia S and
Seger R: The MAPK cascades: Signaling components, nuclear roles and
mechanisms of nuclear translocation. Biochim Biophys Acta.
1813:1619–1633. 2011. View Article : Google Scholar : PubMed/NCBI
|
42
|
Wang X, Hao J, Metzger DL, Ao Z, Chen L,
Ou D, Verchere CB, Mui A and Warnock GL: B7-H4 treatment of T cells
inhibits ERK, JNK, p38, and AKT activation. PLoS One. 7:e282322012.
View Article : Google Scholar : PubMed/NCBI
|
43
|
Afkarian M, Sedy JR, Yang J, Jacobson NG,
Cereb N, Yang SY, Murphy TL and Murphy KM: T-bet is a STAT1-induced
regulator of IL-12R expression in naive CD4+ T cells. Nat Immunol.
3:549–557. 2002. View
Article : Google Scholar : PubMed/NCBI
|
44
|
Wiegand J, van Bömmel F and Berg T:
Management of chronic hepatitis B: Status and challenges beyond
treatment guidelines. Semin Liver Dis. 30:361–377. 2010. View Article : Google Scholar : PubMed/NCBI
|
45
|
Fung J, Lai CL, Yuen J, Cheng C, Wu R,
Wong DK, Seto WK, Hung IF and Yuen MF: Randomized trial of
lamivudine versus entecavir in entecavir-treated patients with
undetectable hepatitis B virus DNA: Outcome at 2 Years. Hepatology.
53:1148–1153. 2011. View Article : Google Scholar : PubMed/NCBI
|