Open Access

Peripheral artery disease and osteoporosis: Not only age‑related (Review)

  • Authors:
    • Agostino Gaudio
    • Anastasia Xourafa
    • Rosario Rapisarda
    • Pietro Castellino
    • Salvatore Santo Signorelli
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  • Published online on: September 27, 2018     https://doi.org/10.3892/mmr.2018.9512
  • Pages: 4787-4792
  • Copyright: © Gaudio et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoporosis and atherosclerosis are two chronic degenerative diseases that share several biochemical pathways and risk factors. Previous studies have associated osteoporosis with carotid atherosclerosis, cardiovascular mortality and stroke, but data on the relationship with peripheral artery disease are few and conflicting. The OPG/RANK/RANKL system and Wnt/beta catenin signaling seem to be deeply involved in the pathogenesis of bone alterations and atherosclerotic processes also affect arteries of the lower extremities. Hypovitaminosis D could also play a role in the relationship of these two diseases. New and larger studies are necessary to shed light on this association and to design new drugs able to act in both these chronic degenerative diseases.
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December-2018
Volume 18 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Gaudio A, Xourafa A, Rapisarda R, Castellino P and Signorelli SS: Peripheral artery disease and osteoporosis: Not only age‑related (Review). Mol Med Rep 18: 4787-4792, 2018.
APA
Gaudio, A., Xourafa, A., Rapisarda, R., Castellino , P., & Signorelli, S.S. (2018). Peripheral artery disease and osteoporosis: Not only age‑related (Review). Molecular Medicine Reports, 18, 4787-4792. https://doi.org/10.3892/mmr.2018.9512
MLA
Gaudio, A., Xourafa, A., Rapisarda, R., Castellino , P., Signorelli, S. S."Peripheral artery disease and osteoporosis: Not only age‑related (Review)". Molecular Medicine Reports 18.6 (2018): 4787-4792.
Chicago
Gaudio, A., Xourafa, A., Rapisarda, R., Castellino , P., Signorelli, S. S."Peripheral artery disease and osteoporosis: Not only age‑related (Review)". Molecular Medicine Reports 18, no. 6 (2018): 4787-4792. https://doi.org/10.3892/mmr.2018.9512