Peripheral artery disease and osteoporosis: Not only age‑related (Review)
- Authors:
- Agostino Gaudio
- Anastasia Xourafa
- Rosario Rapisarda
- Pietro Castellino
- Salvatore Santo Signorelli
-
Affiliations: Department of Clinical and Experimental Medicine, University of Catania, University Hospital ‘G. Rodolico’, I‑95123 Catania, Italy - Published online on: September 27, 2018 https://doi.org/10.3892/mmr.2018.9512
- Pages: 4787-4792
-
Copyright: © Gaudio et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Hirsch AT, Haskal ZJ, Hertzer NR, Bakal CW, Creager MA, Halperin JL, Hiratzka LF, Murphy WR, Olin JW, Puschett JB, et al: ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): A collaborative report from the American association for vascular surgery/society for vascular surgery, society for cardiovascular angiography and interventions, society for vascular medicine and biology, society of interventional radiology and the ACC/AHA task force on practice guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): Endorsed by the American association of cardiovascular and pulmonary rehabilitation; national heart, lung, and blood institute; society for vascular nursing; transatlantic inter-society consensus; and vascular disease foundation. Circulation. 113:e463–e654. 2006.PubMed/NCBI | |
Greenland P, Abrams J, Aurigemma GP, Bond MG, Clark LT, Criqui MH, Crouse JR III, Friedman L, Fuster V, Herrington DM, et al: Prevention conference V: Beyond secondary prevention: Identifying the high-risk patient for primary prevention: Noninvasive tests of atherosclerotic burden: Writing Group III. Circulation. 101:E16–E22. 2000. View Article : Google Scholar : PubMed/NCBI | |
Murabito JM, Evans JC, Nieto K, Larson MG, Levy D and Wilson PW: Prevalence and clinical correlates of peripheral arterial disease in the Framingham offspring study. Am Heart J. 143:961–965. 2002. View Article : Google Scholar : PubMed/NCBI | |
Newman AB, Siscovick DS, Manolio TA, Polak J, Fried LP, Borhani NO and Wolfson SK: Ankle-arm index as a marker of atherosclerosis in the Cardiovascular health study. Cardiovascular heart study (CHS) collaborative research group. Circulation. 88:837–845. 1993. View Article : Google Scholar : PubMed/NCBI | |
Doobay AV and Anand SS: Sensitivity and specificity of the ankle-brachial index to predict future cardiovascular outcomes: A systematic review. Arterioscler Thromb Vasc Biol. 25:1463–1469. 2005. View Article : Google Scholar : PubMed/NCBI | |
Xu D, Zou L, Xing Y, Hou L, Wei Y, Zhang J, Qiao Y, Hu D, Xu Y, Li J and Ma Y: Diagnostic value of ankle-brachial index in peripheral arterial disease: A meta-analysis. Can J Cardiol. 29:492–498. 2013. View Article : Google Scholar : PubMed/NCBI | |
Fowkes FG, Rudan D, Rudan I, Aboyans V, Denenberg JO, McDermott MM, Norman PE, Sampson UK, Williams LJ, Mensah GA and Criqui MH: Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: A systematic review and analysis. Lancet. 382:1329–1340. 2013. View Article : Google Scholar : PubMed/NCBI | |
Selvin E and Erlinger TP: Prevalence of and risk factors for peripheral arterial disease in the United States: Results from the national health and nutrition examination survey, 1999–1999. Circulation. 110:738–743. 2004. View Article : Google Scholar : PubMed/NCBI | |
Carbayo JA, Divisón JA, Escribano J, López-Abril J, de Coca López E, Artigao LM, Martínez E, Sanchis C, Massó J and Carrión L: Grupo de Enfermedades Vasculares de Albacete (GEVA): Using anklebrachial index to detect peripheral arterial disease: Prevalence and associated risk factors in a random population sample. Nutr Metab Cardiovasc Dis. 17:41–49. 2007. View Article : Google Scholar : PubMed/NCBI | |
Sigvant B, Wiberg-Hedman K, Bergqvist D, Rolandsson O, Andersson B, Persson E and Wahlberg E: A population-based study of peripheral arterial disease prevalence with special focus on critical limb ischemia and sex differences. J Vasc Surg. 45:1185–1191. 2007. View Article : Google Scholar : PubMed/NCBI | |
Mostaza JM, Manzano L, Suárez C, Cairols M, Ferreira EM, Rovira E, Sánchez A, Suárez-Tembra MA, Estirado E, Estrella Jde D, et al: Prevalence of asymptomatic peripheral artery disease detected by the ankle-brachial index in patients with cardiovascular disease. MERITO II study). Med Clin (Barc). 131:561–565. 2008. View Article : Google Scholar : PubMed/NCBI | |
Ramos R, Quesada M, Solanas P, Subirana I, Sala J, Vila J, Masiá R, Cerezo C, Elosua R, Grau M, et al: Prevalence of symptomatic and asymptomatic peripheral arterial disease and the value of the ankle-brachial index to stratify cardiovascular risk. Eur J Vasc Endovasc Surg. 38:305–311. 2009. View Article : Google Scholar : PubMed/NCBI | |
Alzamora MT, ForeÂs R, Baena-DõÂez JM, Pera G, Toran P, Sorribes M, Vicheto M, Reina MD, Sancho A, Albaladejo C, et al: The peripheral arterial disease study (PERART/ARTPER): Prevalence and risk factors in the general population. BMC Public Health. 10:382010. View Article : Google Scholar : PubMed/NCBI | |
Aboyans V, Criqui MH, Abraham P, Allison MA, Creager MA, Diehm C, Fowkes FG, Hiatt WR, Jönsson B, Lacroix P, et al: Measurement and interpretation of the ankle-brachial index: A scientific statement from the American heart association. Circulation. 126:2890–2909. 2012. View Article : Google Scholar : PubMed/NCBI | |
Fowkes FG, Rudan D, Rudan I, Aboyans V, Denenberg JO, McDermott MM, Norman PE, Sampson UK, Williams LJ, Mensah GA and Criqui MH: Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: A systematic review and analysis. Lancet. 382:1329–1340. 2013. View Article : Google Scholar : PubMed/NCBI | |
Wilkins JT, McDermott MM, Liu K, Chan C, Criqui MH and Lloyd-Jones DM: Associations of noninvasive measures of arterial compliance and ankle-brachial index: The multi-ethnic study of atherosclerosis (MESA). Am J Hypertens. 25:535–541. 2012. View Article : Google Scholar : PubMed/NCBI | |
Hiatt WR: Medical treatment of peripheral arterial disease and claudication. N Engl J Med. 344:1608–1621. 2001. View Article : Google Scholar : PubMed/NCBI | |
Watson K, Watson BD and Pater KS: Peripheral arterial disease: A review of disease awareness and management. Am J Geriatr Pharmacother. 4:365–379. 2006. View Article : Google Scholar : PubMed/NCBI | |
Signorelli Santo S, Anzaldi M, Fiore V, Catanzaro S, Simili M, Torrisi B and Neri S: Study on unrecognized peripheral arterial disease (PAD) by ankle/brachial index and arterial comorbidity in Catania, Sicily, Italy. Angiology. 61:524–529. 2010. View Article : Google Scholar : PubMed/NCBI | |
Signorelli SS, Fiore V, Catanzaro S, Simili M, Torrisi B and Anzaldi M: Prevalence of high ankle-brachial index (ABI) in general population of Southern Italy, risk factor profiles and systemic cardiovascular co-morbidity: An epidemiological study. Arch Gerontol Geriatr. 53:55–59. 2011. View Article : Google Scholar : PubMed/NCBI | |
Danilevicius CF, Lopes JB and Pereira RM: Bone metabolism and vascular calcification. Braz J Med Biol Res. 40:435–442. 2007. View Article : Google Scholar : PubMed/NCBI | |
Karwowski W, Naumnik B, Szczepański M and Myśliwiec M: The mechanism of vascular calcification-a systematic review. Med Sci Monit. 18:RA1–RA11. 2012. View Article : Google Scholar : PubMed/NCBI | |
Sennerby U, Farahmand B, Ahlbom A, Ljunghall S and Michaëlsson K: Cardiovascular diseases and future risk of hip fracture in women. Osteoporos Int. 18:1355–1362. 2007. View Article : Google Scholar : PubMed/NCBI | |
Marcovitz PA, Tran HH, Franklin BA, O'Neill WW, Yerkey M, Boura J, Kleerekoper M and Dickinson CZ: Usefulness of bone mineral density to predict significant coronary artery disease. Am J Cardiol. 96:1059–1063. 2005. View Article : Google Scholar : PubMed/NCBI | |
Kiel DP, Kauppila LI, Cupples LA, Hannan MT, O'Donnell CJ and Wilson PW: Bone loss and the progression of abdominal aortic calcification over a 25 year period: The Framingham heart study. Calcif Tissue Int. 68:271–276. 2001. View Article : Google Scholar : PubMed/NCBI | |
Barengolts EI, Berman M, Kukreja SC, Kouznetsova T, Lin C and Chomka EV: Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women. Calcif Tissue Int. 62:209–213. 1998. View Article : Google Scholar : PubMed/NCBI | |
Jorgensen L, Joakimsen O, Mathiesen EB, Ahmed L, Berntsen GK, Fønnebø V, Joakimsen R, Njølstad I, Schirmer H and Jacobsen BK: Carotid plaque echogenicity and risk of nonvertebral fractures in women: A longitudinal population-based study. Calcif Tissue Int. 79:207–213. 2006. View Article : Google Scholar : PubMed/NCBI | |
Jørgensen L, Engstad T and Jacobsen BK: Bone mineral density in acute stroke patients: Low bone mineral density may predict first stroke in women. Stroke. 32:47–51. 2001. View Article : Google Scholar : PubMed/NCBI | |
Fehérvári M, Krepuska M, Csobay-Novák C, Lakatos P, Oláh Z, Acsády G and Szeberin Z: Prevalence of osteoporosis in patients with severe peripheral artery disease. Orv Hetil. 154:369–375. 2013. View Article : Google Scholar : PubMed/NCBI | |
Baldwin MJ, Policha A, Maldonado T, Hiramoto JS, Honig S, Conte MS, Berger J and Rockman CB: Novel association between bone mineral density scores and the prevalence of peripheral artery disease in both sexes. Vasc Med. 22:13–20. 2017. View Article : Google Scholar : PubMed/NCBI | |
Mangiafico RA, Russo E, Riccobene S, Pennisi P, Mangiafico M, D'Amico F and Fiore CE: Increased prevalence of peripheral arterial disease in osteoporotic postmenopausal women. J Bone Miner Metab. 24:125–131. 2006. View Article : Google Scholar : PubMed/NCBI | |
Wong SY, Kwok T, Woo J, Lynn H, Griffith JF, Leung J, Tang YY and Leung PC: Bone mineral density and the risk of peripheral arterial disease in men and women: Results from Mr. and Ms Os, Hong Kong. Osteoporos Int. 16:1933–1938. 2005. View Article : Google Scholar : PubMed/NCBI | |
van der Klift M, Pols HA, Hak AE, Witteman JC, Hofman A and de Laet CE: Bone mineral density and the risk of peripheral arterial disease: The rotterdam study. Calcif Tissue Int. 70:443–449. 2002. View Article : Google Scholar : PubMed/NCBI | |
Pasqualini L, Ministrini S, Macura A, Marini E, Leli C, Siepi D, Lombardini R, Kararoudi MN, Scarponi AM, Schillaci G, et al: Increased bone resorption: A possible pathophysiological link between hypovitaminosis D and peripheral arterial disease. Eur J Vasc Endovasc Surg. 52:352–359. 2016. View Article : Google Scholar : PubMed/NCBI | |
Fehérvári M, Sarkadi H, Krepuska M, Sótonyi P, Acsády G, Entz L, Lakatos P and Szeberin Z: Bone mineral density is associated with site-specific atherosclerosis in patients with severe peripheral artery disease. Calcif Tissue Int. 93:55–61. 2013. View Article : Google Scholar : PubMed/NCBI | |
von Mühlen D, Allison M, Jassal SK and Barrett-Connor E: Peripheral arterial disease and osteoporosis in older adults: The rancho bernardo study. Osteoporos Int. 20:2071–2018. 2009. View Article : Google Scholar : PubMed/NCBI | |
Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, et al: Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA. 96:3540–3545. 1999. View Article : Google Scholar : PubMed/NCBI | |
Ziegler S, Kudlacek S, Luger A and Minar E: Osteoprotegerin plasma concentrations correlate with severity of peripheral artery disease. Atherosclerosis. 182:175–180. 2005. View Article : Google Scholar : PubMed/NCBI | |
Pennisi P, Signorelli SS, Riccobene S, Celotta G, Di Pino L, La Malfa T and Fiore CE: Low bone density and abnormal bone turnover in patients with atherosclerosis of peripheral vessels. Osteoporos Int. 15:389–395. 2004. View Article : Google Scholar : PubMed/NCBI | |
Demková K, Kozárová M, Malachovská Z, Javorský M and Tkáč I: Osteoprotegerin concentration is associated with the presence and severity of peripheral arterial disease in type 2 diabetes mellitus. Vasa. 47:131–135. 2018. View Article : Google Scholar : PubMed/NCBI | |
Esteghamati A, Aflatoonian M, Rad MV, Mazaheri T, Mousavizadeh M, Nakhjavani M and Noshad S: Association of osteoprotegerin with peripheral artery disease in patients with type 2 diabetes. Arch Cardiovasc Dis. 108:412–419. 2015. View Article : Google Scholar : PubMed/NCBI | |
Zobel EH, von Scholten BJ, Lajer M, Jorsal A, Tarnow L, Rasmussen LM, Holstein P, Parving HH, Hansen TW and Rossing P: High osteoprotegerin is associated with development of foot ulcer in type 1 diabetes. J Diabetes Complications. 30:1603–1608. 2016. View Article : Google Scholar : PubMed/NCBI | |
O'Sullivan EP, Ashley DT, Davenport C, Kelly J, Devlin N, Crowley R, Leahy AL, Kelly CJ, Agha A, Thompson CJ, et al: Osteoprotegerin is higher in peripheral arterial disease regardless of glycaemic status. Thromb Res. 126:e423–e427. 2010. View Article : Google Scholar : PubMed/NCBI | |
Hosbond SE, Poulsen TS, Diederichsen AC, Nybo M, Rasmussen LM and Mickley H: Osteoprotegerin as a marker of atherosclerosis: A systematic update. Scand Cardiovasc J. 46:203–211. 2012. View Article : Google Scholar : PubMed/NCBI | |
Kapetanios D, Karkos C, Giagtzidis I, Papazoglou K, Kiroplastis K and Spyridis C: Vascular calcification biomarkers and peripheral arterial disease. Int Angiol. 35:455–459. 2016.PubMed/NCBI | |
Ye Z, Ali Z, Klee GG, Mosley TH Jr and Kullo IJ: Associations of candidate biomarkers of vascular disease with the ankle-brachial index and peripheral arterial disease. Am J Hypertens. 26:495–502. 2013. View Article : Google Scholar : PubMed/NCBI | |
Fahrleitner-Pammer A, Obernosterer A, Pilger E, Dobnig H, Dimai HP, Leb G, Kudlacek S and Obermayer-Pietsch BM: Hypovitaminosis D, impaired bone turnover and low bone mass are common in patients with peripheral arterial disease. Osteoporos Int. 16:319–324. 2005. View Article : Google Scholar : PubMed/NCBI | |
Mikhaylova L, Malmquist J and Nurminskaya M: Regulation of in vitro vascular calcification by BMP4, VEGF and Wnt3a. Calcif Tissue Int. 81:372–381. 2007. View Article : Google Scholar : PubMed/NCBI | |
He XW, Wang E, Bao YY, Wang F, Zhu M, Hu XF and Jin XP: High serum levels of sclerostin and Dickkopf-1 are associated with acute ischaemic stroke. Atherosclerosis. 253:22–28. 2016. View Article : Google Scholar : PubMed/NCBI | |
Krishna SM, Seto SW, Jose RJ, Li J, Morton SK, Biros E, Wang Y, Nsengiyumva V, Lindeman JH, Loots GG, et al: Wnt signaling pathway inhibitor sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis. Arterioscler Thromb Vasc Biol. 37:553–566. 2017. View Article : Google Scholar : PubMed/NCBI | |
Kim KM, Lim S, Moon JH, Jin H, Jung KY, Shin CS, Park KS, Jang HC and Choi SH: Lower uncarboxylated osteocalcin and higher sclerostin levels are significantly associated with coronary artery disease. Bone. 83:178–183. 2016. View Article : Google Scholar : PubMed/NCBI | |
Gaudio A, Fiore V, Rapisarda R, Sidoti MH, Xourafa A, Catalano A, Tringali G, Zanoli L, Signorelli SS and Fiore CE: Sclerostin is a possible candidate marker of arterial stiffness: Results from a cohort study in Catania. Mol Med Rep. 15:3420–3424. 2017. View Article : Google Scholar : PubMed/NCBI | |
Popovic DS, Mitrovic M, Tomic-Naglic D, Icin T, Bajkin I, Vukovic B, Benc D, Zivanovic Z, Kovacev-Zavisic B and Stokic E: The Wnt/β-catenin signalling pathway inhibitor sclerostin is a biomarker for early atherosclerosis in obesity. Curr Neurovasc Res. 14:200–206. 2017. View Article : Google Scholar : PubMed/NCBI | |
Morales-Santana S, García-Fontana B, García-Martín A, Rozas-Moreno P, García-Salcedo JA, Reyes-García R and Muñoz-Torres M: Atherosclerotic disease in type 2 diabetes is associated with an increase in sclerostin levels. Diabetes Care. 36:1667–1674. 2013. View Article : Google Scholar : PubMed/NCBI | |
Gaudio A, Privitera F, Pulvirenti I, Canzonieri E, Rapisarda R and Fiore CE: The relationship between inhibitors of the Wnt signalling pathway (sclerostin and Dickkopf-1) and carotid intima-media thickness in postmenopausal women with type 2 diabetes mellitus. Diab Vasc Dis Res. 11:48–52. 2014. View Article : Google Scholar : PubMed/NCBI | |
Saag KG, Petersen J, Brandi ML, Karaplis AC, Lorentzon M, Thomas T, Maddox J, Fan M, Meisner PD and Grauer A: Romosozumab or alendronate for fracture prevention in women with osteoporosis. N Engl J Med. 377:1417–1427. 2017. View Article : Google Scholar : PubMed/NCBI |