Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage

  • Authors:
    • Ya‑Wen Cheng
    • Wen‑Juan Li
    • Xiang‑Jun Dou
    • Rui Jia
    • Hua Yang
    • Xin‑Guang Liu
    • Cang‑Bao Xu
    • Jing Liu
    • Yong‑Xiao Cao
    • Guo‑Gang Luo
  • View Affiliations

  • Published online on: September 27, 2018     https://doi.org/10.3892/mmr.2018.9513
  • Pages: 5229-5236
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Abstract

Cerebral vasospasm (CVS) is a severe complication of subarachnoid hemorrhage (SAH), and endothelin‑1 (ET‑1) may be involved in its pathogenesis. The present study aimed to investigate the expression of ET‑1 in cerebrospinal fluid (CSF) in patients with SAH and to analyze rat arterial contractility and the expression levels of ET‑1 receptors in vitro. CSF samples were collected from 28 patients and the expression levels of ET‑1 were measured. Rat cerebral basilar arteries were isolated and incubated with hemorrhagic or clear CSF. Contractility, as well as ETA and ETB mRNA expression were measured. ET‑1 levels in CSF increased and reached a peak within the initial 5 days after SAH onset and then gradually subsided. After 12 or 24 h, the contraction of arteries incubated in hemorrhagic CSF was substantially stronger than those in clear CSF. The mRNA expression levels of endothelin receptor type A and B in arteries incubated in hemorrhagic CSF were significantly higher than those in clear CSF. ET‑1 and its receptors may be involved in the pathogenic mechanism of CVS following SAH. ET‑1 expression in CSF may be used as a marker in CVS and its receptors may provide novel therapeutic targets in CVS.
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December-2018
Volume 18 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Cheng YW, Li WJ, Dou XJ, Jia R, Yang H, Liu XG, Xu CB, Liu J, Cao YX, Luo GG, Luo GG, et al: Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage. Mol Med Rep 18: 5229-5236, 2018.
APA
Cheng, Y., Li, W., Dou, X., Jia, R., Yang, H., Liu, X. ... Luo, G. (2018). Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage. Molecular Medicine Reports, 18, 5229-5236. https://doi.org/10.3892/mmr.2018.9513
MLA
Cheng, Y., Li, W., Dou, X., Jia, R., Yang, H., Liu, X., Xu, C., Liu, J., Cao, Y., Luo, G."Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage". Molecular Medicine Reports 18.6 (2018): 5229-5236.
Chicago
Cheng, Y., Li, W., Dou, X., Jia, R., Yang, H., Liu, X., Xu, C., Liu, J., Cao, Y., Luo, G."Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage". Molecular Medicine Reports 18, no. 6 (2018): 5229-5236. https://doi.org/10.3892/mmr.2018.9513