Oral microbial flora of patients with Sicca syndrome

Zhou,Shuang; Cai,Ye; Wang,Min; Yang,Wei‑Dong; Duan,Ning

doi:10.3892/mmr.2018.9520

Oral microbial flora of patients with Sicca syndrome

Authors:
- Shuang Zhou
- Ye Cai
- Min Wang
- Wei‑Dong Yang
- Ning Duan
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Affiliations: Department of Microbiological Examination, Jiangsu Institute for Food and Drug Control, Nanjing, Jiangsu 210008, P.R. China, Department of Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210008, P.R. China, School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu 211198, P.R. China, Department of Oral Mucosa, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210008, P.R. China
Published online on: September 27, 2018 https://doi.org/10.3892/mmr.2018.9520
Pages: 4895-4903
Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Primary sicca syndrome (pSS) is a systemic autoimmune disease. However, its exact etiology and pathogenesis remain elusive. Various infectious factors have been identified to be closely associated with the occurrence and development of PSS. The present study aimed to assess the composition of the oral microbial flora of patients with pSS in China in order to provide guidance for treatment. The microbial flora of nine patients with pSS and five healthy controls from East China was evaluated in saliva samples using high‑throughput sequencing. A high microbial diversity was detected in the pSS and control groups, with bacteroidetes, firmicutes and proteobacteria constituting the largest phyla in the two groups. Compared with the control group, bacteroidetes and actinobacteria were significantly more abundant in the pSS group, whereas proteobacteria were significantly less abundant. However, no significant differences in bacterial richness and diversity were observed between the two groups. According to a Kyoto Encyclopedia of Genes and Genomes linear discriminant analysis, genes regulating cell apoptosis and the immune and digestive systems were significantly upregulated in the pSS group compared with those in the control group. In conclusion, the present study provided basic data on the flora of the oral cavity in patients with pSS from East China and may serve as a reference for the treatment of this condition.

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