Mangiferin: An effective therapeutic agent against several disorders (Review)
- Authors:
- Suya Du
- Huirong Liu
- Tiantian Lei
- Xiaofang Xie
- Hailian Wang
- Xia He
- Rongsheng Tong
- Yi Wang
-
Affiliations: Department of Pharmacy, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P.R. China, Institute of Organ Transplantation, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, P.R. China, Personalized Drug Therapy Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China - Published online on: October 2, 2018 https://doi.org/10.3892/mmr.2018.9529
- Pages: 4775-4786
-
Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
 |
 |
 |
 |
 |
|
Dar A, Faizi S, Naqvi S, Roome T, Zikr-ur-Rehman S, Ali M, Firdous S and Moin ST: Analgesic and antioxidant activity of mangiferin and its derivatives: The structure activity relationship. Biol Pharm Bull. 28:596–600. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Duang XY, Wang Q, Zhou XD and Huang DM: Mangiferin: A possible strategy for periodontal disease to therapy. Med Hypotheses. 76:486–488. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Guha S, Ghosal S and Chattopadhyay U: Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone. Chemotherapy. 42:443–451. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Ajila CM, Rao LJ and Rao UJ: Characterization of bioactive compounds from raw and ripe Mangifera indica L. peel extracts. Food Chem Toxicol. 48:3406–3411. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Iseda S: On mangiferin, the coloring matter of mango (Mangifera indica Linn). V. Identification of sugar component and the structure of mangiferin. Bull Chem Soc Jpn. 30:629–633. 1957. View Article : Google Scholar | |
|
Wang Z, Deng J, Wang Q, Li X and Wei H: Improvement in the solubility of mangiferin by HP-β-CD inclusion. Chin Tradit Patent Med. 2008. | |
|
Han D, Chen C, Cong Z, Yu Z and Xing T: Determination of mangiferin in rat plasma by liquid-liquid extraction with UPLC-MS/MS. J Pharm Biomed Anal. 51:260–263. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Liu R, Liu Z, Zhang C and Zhang B: Gelucire44/14 as a novel absorption enhancer for drugs with different hydrophilicities: In vitro and in vivo improvement on transcorneal permeation. J Pharm Sci. 100:3186–3196. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Ma H, Chen H, Sun L, Tong L and Zhang T: Improving permeability and oral absorption of mangiferin by phospholipid complexation. Fitoterapia. 93:54–61. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Saleh F, Mumu SJ, Ara F, Hafez MA and Ali L: Non-adherence to self-care practices & medication and health related quality of life among patients with type 2 diabetes: A cross-sectional study. BMC Public Health. 14:4312014. View Article : Google Scholar : PubMed/NCBI | |
|
Kueh YC, Morris T and Ismail AA: The effect of diabetes knowledge and attitudes on self-management and quality of life among people with type 2 diabetes. Psychol Health Med. 22:138–144. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, Cavan D, Shaw JE and Makaroff LE: IDF diabetes atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 128:40–50. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Xu Y, Wang L, He J, Bi Y, Li M, Wang T, Wang L, Jiang Y, Dai M, Lu J, et al: Prevalence and control of diabetes in Chinese adults. JAMA. 310:948–959. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Barker A, Langenberg C and Wareham NJ: Genetic determinants of glucose homeostasis. Best Pract Res Clin Endocrinol Metab. 26:159–170. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Saltiel AR and Kahn CR: Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 414:799–806. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Göke B: Islet cell function: Alpha and beta cells-partners towards normoglycaemia. Int J Clin Pract Suppl. 62:2–7. 2008. View Article : Google Scholar | |
|
Cusi K: The role of adipose tissue and lipotoxicity in the pathogenesis of type 2 diabetes. Curr Diab Rep. 10:306–315. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Scheen AJ: Pathophysiology of type 2 diabetes. Acta Clin Belg. 58:335–341. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Avogaro A, Giorda C, Maggini M, Mannucci E, Raschetti R, Lombardo F, Spila-Alegiani S, Turco S, Velussi M and Ferrannini E: Diabetes and Informatics Study Group, Association of Clinical Diabetologists, Istituto Superiore di Sanità: Incidence of coronary heart disease in type 2 diabetic men and women: Impact of microvascular complications, treatment, and geographic location. Diabetes Care. 30:1241–1247. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Connelly K, Kelly D and Gilbert R: Clinically relevant models of diabetic cardiac complications. Circ Res. 101:e782007. View Article : Google Scholar : PubMed/NCBI | |
|
De Mattia G, Bravi MC, Laurenti O, Moretti A, Cipriani R, Gatti A, Mandosi E and Morano S: Endothelial dysfunction and oxidative stress in type 1 and type 2 diabetic patients without clinical macrovascular complications. Diabetes Res Clin Pract. 79:337–342. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Happich M, Breitscheidel L, Meisinger C, Ulbig M, Falkenstein P, Benter U and Watkins J: Cross-sectional analysis of adult diabetes type 1 and type 2 patients with diabetic microvascular complications from a German retrospective observational study. Curr Med Res Opin. 23:1367–1374. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Cohen A and Horton ES: Progress in the treatment of type 2 diabetes: New pharmacologic approaches to improve glycemic control. Curr Med Res Opin. 23:905–917. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Carpino PA and Goodwin B: Diabetes area participation analysis: A review of companies and targets described in the 2008–2008 patent literature. Expert Opin Ther Pat. 20:1627–1651. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Sellamuthu PS, Arulselvan P, Fakurazi S and Kandasamy M: Beneficial effects of mangiferin isolated from Salacia chinensis on biochemical and hematological parameters in rats with streptozotocin-induced diabetes. Pak J Pharm Sci. 27:161–167. 2014.PubMed/NCBI | |
|
Sellamuthu PS, Muniappan BP, Perumal SM and Kandasamy M: Antihyperglycemic effect of mangiferin in streptozotocin induced diabetic rats. J Health Sci. 55:206–214. 2009. View Article : Google Scholar | |
|
Saleh S, El-Maraghy N, Reda E and Barakat W: Modulation of diabetes and dyslipidemia in diabetic insulin-resistant rats by mangiferin: Role of adiponectin and TNF-α. An Acad Bras Cienc. 86:1935–1948. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Muruganandan S, Srinivasan K, Gupta S, Gupta PK and Lal J: Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats. J Ethnopharmacol. 97:497–501. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Miura T, Iwamoto N, Kato M, Ichiki H, Kubo M, Komatsu Y, Ishida T, Okada M and Tanigawa K: The suppressive effect of mangiferin with exercise on blood lipids in type 2 diabetes. Biol Pharm Bull. 24:1091–1092. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Miura T, Ichiki H, Hashimoto I, Iwamoto N, Kato M, Kubo M, Ishihara E, Komatsu Y, Okada M, Ishida T and Tanigawa K: Antidiabetic activity of a xanthone compound, mangiferin. Phytomedicine. 8:85–87. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Kumar SR, Ray MI, Ujwala M, Borde MK and Deshmukh YA: Natural dipeptidyl peptidase-IV inhibitor mangiferin mitigates diabetes- and metabolic syndrome-induced changes in experimental rats. Diabetes Metab Syndr Obes. 9:261–272. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Wang HL, Li CY, Zhang B, Liu YD, Lu BM, Shi Z, An N, Zhao LK, Zhang JJ, Bao JK and Wang Y: Mangiferin facilitates islet regeneration and β-cell proliferation through upregulation of cell cycle and β-cell regeneration regulators. Int J Mol Sci. 15:9016–9035. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Duran-Salgado MB and Rubio-Guerra AF: Diabetic nephropathy and inflammation. World J Diabetes. 5:393–398. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Pal PB, Sinha K and Sil PC: Mangiferin attenuates diabetic nephropathy by inhibiting oxidative stress mediated signaling cascade, TNFα related and mitochondrial dependent apoptotic pathways in streptozotocin-induced diabetic rats. PLoS One. 9:e1072202014. View Article : Google Scholar : PubMed/NCBI | |
|
Liu YW, Zhu X, Zhang L, Lu Q, Wang JY, Zhang F, Guo H, Yin JL and Yin XX: Up-regulation of glyoxalase 1 by mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats. Eur J Pharmacol. 721:355–364. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu X, Cheng YQ, Du L, Li Y, Zhang F, Guo H, Liu YW and Yin XX: Mangiferin attenuates renal fibrosis through down-regulation of osteopontin in diabetic rats. Phytother Res. 29:295–302. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Gaede P, Vedel P, Larsen N, Jensen GV, Parving HH and Pedersen O: Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med. 348:383–393. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Kannel WB and McGee DL: Diabetes and cardiovascular disease: The Framingham Study. JAMA. 241:2035–2038. 1979. View Article : Google Scholar : PubMed/NCBI | |
|
Manson JE, Colditz GA, Stampfer MJ, Willett WC, Krolewski AS, Rosner B, Arky RA, Speizer FE and Hennekens CH: A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women. Arch Intern Med. 151:1141–1147. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Ramasamy R, Yan SF and Schmidt AM: Receptor for AGE (RAGE): Signaling mechanisms in the pathogenesis of diabetes and its complications. Ann N Y Acad Sci. 1243:88–102. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Suchal K, Malik S, Khan SI, Malhotra RK, Goyal SN, Bhatia J, Kumari S, Ojha S and Arya DS: Protective effect of mangiferin on myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats: Role of AGE-RAGE/MAPK pathways. Sci Rep. 7:420272017. View Article : Google Scholar : PubMed/NCBI | |
|
Hou J, Zheng D, Fung G, Deng H, Chen L, Liang J, Jiang Y and Hu Y: Mangiferin suppressed advanced glycation end products (AGEs) through NF-κB deactivation and displayed anti-inflammatory effects in streptozotocin and high fat diet-diabetic cardiomyopathy rats. Can J Physiol Pharmacol. 94:332–340. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Hou J, Zheng D, Zhong G and Hu Y: Mangiferin mitigates diabetic cardiomyopathy in streptozotocin-diabetic rats. Can J Physiol Pharmacol. 91:759–763. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Basha B, Samuel SM, Triggle CR and Ding H: Endothelial dysfunction in diabetes mellitus: possible involvement of endoplasmic reticulum stress? Exp Diabetes Res. 2012:4818402012. View Article : Google Scholar : PubMed/NCBI | |
|
Song J, Li J, Hou F, Wang X and Liu B: Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells. Metabolism. 64:428–437. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Barascu A, Besson P, Le Floch O, Bougnoux P and Jourdan ML: CDK1-cyclin B1 mediates the inhibition of proliferation induced by omega-3 fatty acids in MDA-MB-231 breast cancer cells. Int J Biochem Cell Biol. 38:196–208. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Miyazaki T and Arai S: Two distinct controls of mitotic cdk1/cyclin B1 activity requisite for cell growth prior to cell division. Cell Cycle. 6:1419–1425. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Porter LA and Donoghue DJ: Cyclin B1 and CDK1: Nuclear localization and upstream regulators. Prog Cell Cycle Res. 5:335–347. 2003.PubMed/NCBI | |
|
Hu X and Moscinski LC: Cdc2: A monopotent or pluripotent CDK? Cell Prolif. 44:205–211. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Peng ZG, Yao YB, Yang J, Tang YL and Huang X: Mangiferin induces cell cycle arrest at G2/M phase through ATR-Chk1 pathway in HL-60 leukemia cells. Genet Mol Res. 14:4989–5002. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Yao YB, Peng ZG, Liu ZF, Yang J and Luo J: Effects of mangiferin on cell cycle status and CDC2/Cyclin B1 expression of HL-60 cells. Zhong Yao Cai. 33:81–85. 2010.(In Chinese). PubMed/NCBI | |
|
du Plessis-Stoman D, du Preez J and van de Venter M: Combination treatment with oxaliplatin and mangiferin causes increased apoptosis and downregulation of NFκB in cancer cell lines. Afr J Tradit Complement Altern Med. 8:177–184. 2011.PubMed/NCBI | |
|
Dolcet X, Llobet D, Pallares J and Matias-Guiu X: NF-kB in development and progression of human cancer. Virchows Archiv. 446:475–382. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
García-Rivera D, Delgado R, Bougarne N, Haegeman G and Berghe WV: Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells. Cancer Lett. 305:21–31. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Shi W, Deng J, Tong R, Yang Y, He X, Lv J, Wang H, Deng S, Qi P, Zhang D and Wang Y: Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells. Mol Med Rep. 13:3423–3432. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Telang M, Dhulap S, Mandhare A and Hirwani R: Therapeutic and cosmetic applications of mangiferin: A patent review. Expert Opin Ther Pat. 23:1561–1580. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Pomerantz JL and Baltimore D: Two pathways to NF-kappaB. Mol Cell. 10:693–695. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Kawasaki H, Toyoda M, Shinohara H, Okuda J, Watanabe I, Yamamoto T, Tanaka K, Tenjo T and Tanigawa N: Expression of survivin correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis. Cancer. 91:2026–2032. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Budihardjo I, Oliver H, Lutter M, Luo X and Wang X: Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol. 15:269–290. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Pan LL, Wang AY, Huang YQ, Luo Y and Ling M: Mangiferin induces apoptosis by regulating Bcl-2 and Bax expression in the CNE2 nasopharyngeal carcinoma cell line. Asian Pac J Cancer Prev. 15:7065–7068. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kim H, Kim H, Mosaddik A, Gyawali R, Ahn KS and Cho SK: Induction of apoptosis by ethanolic extract of mango peel and comparative analysis of the chemical constitutes of mango peel and flesh. Food Chem. 133:416–422. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Lv J, Wang Z, Zhang L, Wang HL, Liu Y, Li C, Deng J, Wang Y and Bao JK: Mangiferin induces apoptosis and cell cycle arrest in MCF-7 cells both in vitro and in vivo. J Anim Vet Adv. 12:352–359. 2013. | |
|
Zou B, Wang H, Liu Y, Qi P, Lei T, Sun M and Wang Y: Mangiferin induces apoptosis in human ovarian adenocarcinoma OVCAR3 cells via the regulation of Notch3. Oncol Rep. 38:1431–1441. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Saha S, Sadhukhan P and Sil PC: Mangiferin: A xanthonoid with multipotent anti-inflammatory potential. Biofactors. 42:459–474. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Bera S, Chaudhuri S and Dutta D: Assessment of free-radical scavenging activities of mangiferin from Curcuma amada obtained by non-conventional extraction methods: A comparative study. Indian J Biotechnol. 14:179–185. 2015. | |
|
Abdul-Muneer PM, Chandra N and Haorah J: Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury. Mol Neurobiol. 51:966–979. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Fujiwara N, Som AT, Pham LD, Lee BJ, Mandeville ET, Lo EH and Arai K: A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model. Neurosci Lett. 633:7–13. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ren Y, Wei B, Song X, An N, Zhou Y, Jin X and Zhang Y: Edaravone's free radical scavenging mechanisms of neuroprotection against cerebral ischemia: Review of the literature. Int J Neurosci. 125:555–565. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Lewén A, Matz P and Chan PH: Free radical pathways in CNS injury. J Neurotrauma. 17:871–890. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Fu Y, Liu H, Song C, Zhang F, Liu Y, Wu J, Wen X, Liang C, Ma K, Li L, et al: Mangiferin regulates cognitive deficits and heme oxygenase-1 induced by lipopolysaccharide in mice. Int Immunopharmacol. 29:950–956. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Jangra A, Lukhi MM, Sulakhiya K, Baruah CC and Lahkar M: Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice. Eur J Pharmacol. 740:337–347. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Bhatia HS, Candelario-Jalil E, de Oliveira AC, Olajide OA, Martínez-Sánchez G and Fiebich BL: Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E 2 production in activated rat microglial cells. Arch Biochem Biophys. 477:253–258. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Márquez L, García-Bueno B, Madrigal JL and Leza JC: Mangiferin decreases inflammation and oxidative damage in rat brain after stress. Eur J Nutr. 51:729–739. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Z, Guo S, Wang J, Shen Y, Zhang J and Wu Q: Nrf2/HO-1 mediates the neuroprotective effect of mangiferin on early brain injury after subarachnoid hemorrhage by attenuating mitochondria-related apoptosis and neuroinflammation. Sci Rep. 7:118832017. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Z, Weian C, Susu H and Hanmin W: Protective effects of mangiferin on cerebral ischemia-reperfusion injury and its mechanisms. Eur J Pharmacol. 771:145–151. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Prabhu S, Jainu M, Sabitha KE and Devi CS: Role of mangiferin on biochemical alterations and antioxidant status in isoproterenol-induced myocardial infarction in rats. J Ethnopharmacol. 107:126–133. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Prabhu S, Jainu M, Sabitha KE and Devi CS: Cardioprotective effect of mangiferin on isoproterenol induced myocardial infarction in rats. Indian J Exp Biol. 44:209–215. 2006.PubMed/NCBI | |
|
Prabhu S, Jainu M, Sabitha KE and Devi Shyamala CS: Effect of mangiferin on mitochondrial energy production in experimentally induced myocardial infarcted rats. Vascul Pharmacol. 44:519–525. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Prabhu S, Narayan S and Devi C: Mechanism of protective action of mangiferin on suppression of inflammatory response and lysosomal instability in rat model of myocardial infarction. Phytother Res. 23:756–760. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng D, Hou J, Xiao Y, Zhao Z and Chen L: Cardioprotective effect of mangiferin on left ventricular remodeling in rats. Pharmacology. 90:78–87. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Arozal W, Suyatna FD, Juniantito V, Rosdiana DS, Amurugam S, Aulia R, Monayo ER and Siswandi R: The effects of mangiferin (Mangifera indica L) in doxorubicin-induced cardiotoxicity in rats. Drug Res (Stuttg). 65:574–580. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Nordestgaard BG and Varbo A: Triglycerides and cardiovascular disease. Lancet. 384:626–635. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Alberto Nú?ez-Sellés J: Antioxidant therapy: myth or reality? J Braz Chem Soc. 16:699–710. 2005. View Article : Google Scholar | |
|
Pardo-Andreu GL, Paim BA, Castilho RF, Velho JA, Delgado R, Vercesi AE and Oliveira HC: Mangifera indica L: extract (Vimang) and its main polyphenol mangiferin prevent mitochondrial oxidative stress in atherosclerosis-prone hypercholesterolemic mouse. Pharmacol Res. 57:332–338. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Guo F, Huang C, Liao X, Wang Y, He Y, Feng R, Li Y and Sun C: Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters. Mol Nutr Food Res. 55:1809–1818. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Niu Y, Li S, Na L, Feng R, Liu L, Ying L and Sun C: Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK. PLoS One. 7:e307822012. View Article : Google Scholar : PubMed/NCBI | |
|
Na L, Zhang Q, Jiang S, Du S, Zhang W, Li Y, Sun C and Niu Y: Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: A double-blind randomized controlled trial. Sci Rep. 5:103442015. View Article : Google Scholar : PubMed/NCBI | |
|
Apontes P, Liu Z, Su K, Benard O, Youn DY, Li X, Li W, Mirza RH, Bastie CC, Jelicks LA, et al: Mangiferin stimulates carbohydrate oxidation and protects against metabolic disorders induced by high-fat diets. Diabetes. 63:3626–3636. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Lim J, Liu Z, Apontes P, Feng D, Pessin JE, Sauve AA, Angeletti RH and Chi Y: Dual mode action of mangiferin in mouse liver under high fat diet. PLoS One. 9:e901372014. View Article : Google Scholar : PubMed/NCBI | |
|
Takagi A and Tada Y: Medical applicability of cultured vascular endothelial cells in cardiovascular surgery. Jpn J Cardiovasc Surg. 19:45–52. 1989. View Article : Google Scholar | |
|
Lahera V, Navarro-Cid J, Maeso R and Cachofeiro V: Participation of endothelium-derived vasoconstrictor factors in arterial hypertension. Rev Esp Cardiol. 52 Suppl 3:S4–S11. 1999.(In Spanish). | |
|
He Q, Ai J and Huang Y: Relationship between endothelial damage and p120-catenin in paraquat intoxication and the protective effect of mangiferin. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 26:369–373. 2014.(In Chinese). PubMed/NCBI | |
|
Luo F, Lv Q, Zhao Y, Hu G, Huang G, Zhang J, Sun C, Li X and Chen K: Quantification and purification of mangiferin from Chinese Mango (Mangifera indica L.) cultivars and its protective effect on human umbilical vein endothelial cells under H(2)O(2)-induced stress. Int J Mol Sci. 13:11260–11274. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Venugopal R, Sakthisekaran D, Rajkapoor B and Nishigaki I: In vitro protective effect of mangiferin against glycated protein-iron chelate induced toxicity in human umbilical vein endothelial cells. J Biol Sci. 7:1227–1232. 2007. View Article : Google Scholar | |
|
Vieira AB, Coelho LP, Insuela DB, Carvalho VF, dos Santos MH, Silva PM and Martins MA: Mangiferin prevents guinea pig tracheal contraction via activation of the nitric oxide-cyclic GMP pathway. Plos One. 8:e717592013. View Article : Google Scholar : PubMed/NCBI | |
|
Rivera DG, Hernández I, Merino N, Luque Y, Álvarez A, Martín Y, Amador A, Nuevas L and Delgado R: Mangifera indica L. extract (Vimang) and mangiferin reduce the airway inflammation and Th2 cytokines in murine model of allergic asthma. J Pharm Pharmacol. 63:1336–1345. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Cohen JC, Horton JD and Hobbs HH: Human fatty liver disease. Old questions and new insights. Science. 332:1519–1523. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Guo Y and Xia C: Research progress of pharmacological action and clinical application in tibetan medicine ‘Zangyinchen’. Asia Pac Tradit Med. 2016. | |
|
Tan L, Feng-Zu HU and Dong Q: Simultaneous determination of three iridoid glycosides and three flavonoids in Swertia mussotii Franch. from Qinghai by UPLC. Chin J Pharm Anal. 2017. | |
|
Pal PB, Sinha K and Sil PC: Mangiferin, a natural xanthone, protects murine liver in Pb(II) induced hepatic damage and cell death via MAP kinase, NF-κB and mitochondria dependent pathways. PLoS One. 8:e568942013. View Article : Google Scholar : PubMed/NCBI | |
|
Rasool M, Sabina EP, Mahinda PS and Gnanaselvi BC: Mangiferin, a natural polyphenol protects the hepatic damage in mice caused by CCl 4 intoxication. Comp Clin Pathol. 21:865–872. 2012. View Article : Google Scholar | |
|
Pan CW, Pan ZZ, Hu JJ, Chen WL, Zhou GY, Lin W, Jin LX and Xu CL: Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation. Eur J Pharmacol. 770:85–91. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Xing X, Li D, Chen D, Zhou L, Chonan R, Yamahara J, Wang J and Li Y: Mangiferin treatment inhibits hepatic expression of acyl-coenzyme A: Diacylglycerol acyltransferase-2 in fructose-fed spontaneously hypertensive rats: A link to amelioration of fatty liver. Toxicol Appl Pharmacol. 280:207–215. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
He F, Zeng X, Wei G, Wen Y, Su H, Wei B, et al: Choleretic action and spasmolysis of gallbladder smooth muscle of mangiferin. China Pharmacist. 2014. | |
|
Makare N, Bodhankar S and Rangari V: Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice. J Ethnopharmacol. 78:133–137. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Sahu S, Das BK, Pradhan J, Mohapatra BC, Mishra BK and Sarangi N: Effect of Magnifera indica kernel as a feed additive on immunity and resistance to Aeromonas hydrophila in Labeo rohita fingerlings. Fish Shellfish Immunol. 23:109–118. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
García D, Leiro J, Delgado R, Sanmartín ML and Ubeira FM: Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune responses. Phytother Res. 17:1182–1187. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Muruganandan S, Lal J and Gupta PK: Immunotherapeutic effects of mangiferin mediated by the inhibition of oxidative stress to activated lymphocytes, neutrophils and macrophages. Toxicology. 215:57–68. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Miura T, Ichiki H, Iwamoto N, Kato M, Kubo M, Sasaki H, Okada M, Ishida T, Seino Y and Tanigawa K: Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside. Biol Pharm Bull. 24:1009–1011. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Kim CY, Ahn MJ and Kim J: Preparative isolation of mangiferin from anemarrhena asphodeloides rhizomes by centrifugal partition chromatography. J Liq Chromatogr Relat Technol. 29:869–875. 2006. View Article : Google Scholar | |
|
Maji HS, Maji S, Roy R, Sen A and Biswas T: Isolation of mangiferin from flowering buds of mangifera indica l and its evaluation of in vitro antibacterial activity. JPA. 4:49–56. 2015. | |
|
Zheng MS and Lu ZY: Antiviral effect of mangiferin and isomangiferin on herpes simplex virus. Chin Med J (Engl). 103:160–165. 1990.PubMed/NCBI | |
|
Zhu XM, Song JX, Huang ZZ, Wu YM and Yu MJ: Antiviral activity of mangiferin against herpes simplex virus type 2 in vitro. Zhongguo Yao Li Xue Bao. 14:452–454. 1993.(In Chinese). PubMed/NCBI | |
|
García D, Escalante M, Delgado R, Ubeira FM and Leiro J: Anthelminthic and antiallergic activities of Mangifera indica L. stem bark components Vimang and mangiferin. Phytother Res. 17:1203–1208. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Ochocka R, Hering A, Stefanowicz-Hajduk J, Cal K and Barańska H: The effect of mangiferin on skin: Penetration, permeation and inhibition of ECM enzymes. PLoS One. 12:e01815422017. View Article : Google Scholar : PubMed/NCBI |
