Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia

Li,Hua; Cheng,Zijie; Tang,Yuanyuan; Feng,Mengwen; Yin,Anwen; Zhang,Hao; Xu,Jia; Zhang,Qijun; Zhang,Jinsong; Qian,Lingmei

doi:10.3892/mmr.2018.9658

Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia

Authors:
- Hua Li
- Zijie Cheng
- Yuanyuan Tang
- Mengwen Feng
- Anwen Yin
- Hao Zhang
- Jia Xu
- Qijun Zhang
- Jinsong Zhang
- Lingmei Qian
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Affiliations: Department of Emergency, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Departmant of General Medicine, Traditional Chinese Medicine Hospital of Jiangsu Province, Nanjing, Jiangsu 210004, P.R. China, Department of Cardiology, YinZhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, Zhejiang 315040, P.R. China
Published online on: November 13, 2018 https://doi.org/10.3892/mmr.2018.9658
Pages: 302-308
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute myocardial infarction (AMI) is a life‑threatening disease and seriously influences patient quality of life. Long non‑coding RNAs (lncRNAs), an emerging class of non‑coding genes, have attracted attention in research, however, whether lncRNAs serve a function in acute ischemic hypoxia remains to be elucidated. In the present study, an lncRNA microarray was used to analyze differential lncRNA expression in acute ischemic hypoxia. A total of 323 lncRNAs were identified, 168 of which were upregulated and 155 of which were downregulated. Gene Ontology and Pathway analyses were also used to identify the potential functions of dysregulated lncRNAs; it was predicted that these dysregulated lncRNAs may contribute to the initiation of AMI. It was demonstrated that an lncRNA termed sloyfley may influence acute ischemic hypoxia through its neighboring gene Peg3, which has been linked to brain ischemia hypoxia. In summary, the present study identified numerous lncRNAs, which may provide further opportunities for the development of novel therapeutic strategies.

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