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Contribution of regulatory T cells to immune tolerance and association of microRNA‑210 and Foxp3 in preeclampsia

  • Authors:
    • Jiying Chen
    • Lijian Zhao
    • Dengchuan Wang
    • Yanbin Xu
    • Haijie Gao
    • Wenqing Tan
    • Chenhong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Maternal and Children's Hospital of Shenzhen City, Southern Medical University, Shenzhen, Guangdong 518000, P.R. China, Department of Obstetrics and Gynecology, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong 518110, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1150-1158
    |
    Published online on: December 10, 2018
       https://doi.org/10.3892/mmr.2018.9733
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Abstract

Increasing evidence suggests that an exaggerated maternal systemic inflammatofrery response may play a central role in the pathogenesis of preeclampsia (PE). Considering the growing evidence on microRNAs (miRNAs) and tissue‑specific regulators of gene expression, we investigated the potential association of miR‑210 and forkhead box p3 (Foxp3) in preeclamptic patients. Serum levels of the cytokines interleukin (IL)‑6, IL‑10, IL‑17, and transforming grown factor‑β1 were detected with ELISA. Reverse‑transcription‑quantitative polymerase chain reaction was performed to detect mRNA expression for maternal placenta retinoic acid‑related orphan receptor C, Foxp3 and miRNA (miR)‑210. Foxp3 protein expression was evaluated by western blot analysis. Serum levels of cytokines IL‑10 were significantly lower in preeclamptic patients than in normal pregnant women. mRNA expression of Foxp3 was significantly lower in placenta of PE. mRNA expression of miR‑210 was significantly increased in PE. Results of western blot analysis indicated that Foxp3 protein expression was lower in PE than in normal pregnant women. Our data suggest that PE manifests as a decreased number of regulatory T cells (Tregs), which regulate maternal tolerance of the fetus. In placenta from women with PE, compared with normal pregnant women, mRNA expression of Foxp3 was significantly decreased, and expression of miR‑210 was significantly increased.
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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Zhao L, Wang D, Xu Y, Gao H, Tan W and Wang C: Contribution of regulatory T cells to immune tolerance and association of microRNA‑210 and Foxp3 in preeclampsia. Mol Med Rep 19: 1150-1158, 2019.
APA
Chen, J., Zhao, L., Wang, D., Xu, Y., Gao, H., Tan, W., & Wang, C. (2019). Contribution of regulatory T cells to immune tolerance and association of microRNA‑210 and Foxp3 in preeclampsia. Molecular Medicine Reports, 19, 1150-1158. https://doi.org/10.3892/mmr.2018.9733
MLA
Chen, J., Zhao, L., Wang, D., Xu, Y., Gao, H., Tan, W., Wang, C."Contribution of regulatory T cells to immune tolerance and association of microRNA‑210 and Foxp3 in preeclampsia". Molecular Medicine Reports 19.2 (2019): 1150-1158.
Chicago
Chen, J., Zhao, L., Wang, D., Xu, Y., Gao, H., Tan, W., Wang, C."Contribution of regulatory T cells to immune tolerance and association of microRNA‑210 and Foxp3 in preeclampsia". Molecular Medicine Reports 19, no. 2 (2019): 1150-1158. https://doi.org/10.3892/mmr.2018.9733
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Zhao L, Wang D, Xu Y, Gao H, Tan W and Wang C: Contribution of regulatory T cells to immune tolerance and association of microRNA‑210 and Foxp3 in preeclampsia. Mol Med Rep 19: 1150-1158, 2019.
APA
Chen, J., Zhao, L., Wang, D., Xu, Y., Gao, H., Tan, W., & Wang, C. (2019). Contribution of regulatory T cells to immune tolerance and association of microRNA‑210 and Foxp3 in preeclampsia. Molecular Medicine Reports, 19, 1150-1158. https://doi.org/10.3892/mmr.2018.9733
MLA
Chen, J., Zhao, L., Wang, D., Xu, Y., Gao, H., Tan, W., Wang, C."Contribution of regulatory T cells to immune tolerance and association of microRNA‑210 and Foxp3 in preeclampsia". Molecular Medicine Reports 19.2 (2019): 1150-1158.
Chicago
Chen, J., Zhao, L., Wang, D., Xu, Y., Gao, H., Tan, W., Wang, C."Contribution of regulatory T cells to immune tolerance and association of microRNA‑210 and Foxp3 in preeclampsia". Molecular Medicine Reports 19, no. 2 (2019): 1150-1158. https://doi.org/10.3892/mmr.2018.9733
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