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Expression of C1q in the serum of patients with non‑severe aplastic anemia, and its association with disease severity

  • Authors:
    • Shaoxue Ding
    • Chunyan Liu
    • Yang Li
    • Hui Liu
    • Zhaoyun Liu
    • Tong Chen
    • Tian Zhang
    • Zonghong Shao
    • Rong Fu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1194-1202
    |
    Published online on: December 12, 2018
       https://doi.org/10.3892/mmr.2018.9754
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Abstract

A type of aplastic anemia (AA), non-severe aplastic anemia (NSAA) is defined as AA that does not meet the diagnostic criteria of severe aplastic anemia (SAA). Complement component 1q (C1q) has an important role in the pathogenesis of various autoimmune diseases; however, the role of C1q in the immune pathogenesis of NSAA is not clear. The current study aimed to determine whether C1q has an important role in the pathogenesis of NSAA. Isobaric tags for relative and absolute quantitation (iTRAQ) was used to compare the protein expression in bone marrow mononuclear cells from patients with NSAA and healthy volunteers. Pathway enrichment analysis was performed to determine the biological functions involved in NSAA. The differential expression of C1q was marked compared with other proteins. Subsequently, the concentration of C1q in serum samples was determined using ELISA and the correlation of C1q levels and NSAA severity was evaluated. The serum concentrations of C1q were significantly lower in untreated patients with newly diagnosed NSAA compared with NSAA cases in remission and normal controls. Furthermore, there was no significant difference in C1q concentration between newly diagnosed patients with NSAA and patients with autoimmune hemolytic anemia or immune thrombocytopenia. The serum concentration of C1q in newly diagnosed NSAA was significantly lower in patients with SAA (P<0.0001); whereas, there was no significant difference between the patients with SAA, patients with NSAA remission and normal controls (P>0.05). Additionally, the serum C1q concentration was significantly correlated with granulocyte counts, the level of hemoglobin, platelet counts, reticulocyte percentage and remission in patients with NSAA. The serum C1q concentration was also positively correlated with the myeloid/plasmacytoid dendritic cell ratio, and negatively correlated with the CD4(+)/CD8(+) ratio. These findings suggested that C1q may be a reliable serological marker for monitoring and evaluating disease severity in patients with NSAA. C1q may have an important role in the immune pathogenesis of NSAA.
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1 

Camitta BM, Thomas ED, Nathan DG, Santos G, Gordon-Smith EC, Gale RP, Rappeport JM and Storb R: Severe aplastic anemia: A prospective study of the effect of early marrow transplantation on acute mortality. Blood. 48:63–70. 1976.PubMed/NCBI

2 

Boddu PC and Kadia TM: Updates on the pathophysiology and treatment of aplastic anemia: A comprehensive review. Expert Rev Hematol. 10:433–448. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Bacigalupo A: How I treat acquired aplastic anemia. Blood. 129:1428–1436. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Dezern AE and Brodsky RA: Clinical management of aplastic anemia. Expert Rev Hematol. 4:221–230. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Kwon JH, Kim I, Lee YG, Koh Y, Park HC, Song EY, Kim HK, Yoon SS, Lee DS, Park SS, et al: Clinical course of non-severe aplastic anemia in adults. Int J Hematol. 91:770–775. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Young NS: Current concepts in the pathophysiology and treatment of aplastic anemia. Hematology Am Soc Hematol Educ Program. 2013:76–81. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Brodsky RA and Jones RJ: Aplastic anaemia. Lancet. 365:1647–1656. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Stanley N, Olson TS and Babushok DV: Recent advances in understanding clonal haematopoiesis in aplastic anaemia. Br J Haematol. 177:509–525. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Wang YH, Fu R, Dong SW, Liu H and Shao ZH: Erythroblastic islands in the bone marrow of patients with immune-related pancytopenia. PLoS One. 9:e951432014. View Article : Google Scholar : PubMed/NCBI

10 

Liu H, Fu R, Li L, Ding K, Wang Y, Wang H, Zhang T, Wang G, Song J and Shao Z: Erythropoietin receptors and IgG autoantibody expression on nucleated erythrocytes in some cases of immuno-related pancytopenia. Clin Lab. 61:693–698. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Thurman JM, Frazer-Abel A and Holers VM: The evolving landscape for complement therapeutics in rheumatic and autoimmune diseases. Arthritis Rheumatol. 69:2102–2113. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Ballanti E, Perricone C, Greco E, Ballanti M, Di Muzio G, Chimenti MS and Perricone R: Complement and autoimmunity. Immunol Res. 56:477–491. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Sontheimer RD, Racila E and Racila DM: C1q: Its functions within the innate and adaptive immune responses and its role in lupus autoimmunity. J Invest Dermatol. 125:14–23. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC, Keidan J, Laurie A, Martin A, Mercieca J, et al: Guidelines for the diagnosis and management of aplastic anaemia. Br J Haematol. 147:43–70. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Fu R, Uehara T, Gong L and Shao ZH: Study on the pathogenesis of blood cytopenia in patients with systemic lupus erythematosus. Zhonghua Xue Ye Xue Za Zhi. 29:48–51. 2008.(In Chinese). PubMed/NCBI

16 

Moore CD, Ajala OZ and Zhu H: Applications in high-content functional protein microarrays. Curr Opin Chem Biol. 30:21–27. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Ardekani AM, Akhondi MM and Sadeghi MR: Application of genomic and proteomic technologies to early detection of cancer. Arch Iran Med. 11:427–434. 2008.PubMed/NCBI

18 

Sui W, Tang D, Zou T, Zou G, Chen J, Li H, Li L, Hou Y, Li H and Dai Y: Differential proteomic analysis of renal tissue in mesangial proliferative glomerulonephritis using iTRAQ technology. J Nephrol. 26:191–198. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Thomas SN, Zhang H and Cotter RJ: Application of quantitative proteomics to the integrated analysis of the ubiquitylated and global proteomes of xenograft tumor tissues. Clin Proteomics. 12:142015. View Article : Google Scholar : PubMed/NCBI

20 

Serada S and Naka T: Screening for novel serum biomarker for monitoring disease activity in rheumatoid arthritis using iTRAQ technology-based quantitative proteomic approach. Methods Mol Biol. 1142:99–110. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Fujita T, Matsushita M and Endo Y: The lectin-complement pathway-its role in innate immunity and evolution. Immunol Rev. 198:185–202. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Duncan AR and Winter G: The binding site for C1q on IgG. Nature. 332:738–740. 1988. View Article : Google Scholar : PubMed/NCBI

23 

Sellar GC, Blake DJ and Reid KB: Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q. Biochem J. 274:481–490. 1991. View Article : Google Scholar : PubMed/NCBI

24 

Tsang-A-Sjoe MWP, Bultink IEM, Korswagen LA, van der Horst A, Rensink I, de Boer M, Hamann D, Voskuyl AE and Wouters D: Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity. Mol Immunol. 92:125–131. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Ghebrehiwet B, Hosszu KH and Peerschke EI: C1q as an autocrine and paracrine regulator of cellular functions. Mol Immunol. 84:26–33. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Alsuwaida A, Husain S, Al Ghonaim M, Aloudah N, Ullah A and Kfoury H: Prognostic significance of C1q deposition in serial biopsies for predicating the long-term outcome in patients with proliferative lupus nephritis. Saudi J Kidney Dis Transpl. 27:305–311. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Botto M and Walport MJ: C1q, autoimmunity and apoptosis. Immunobiology. 205:395–406. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Pickering MC, Botto M, Taylor PR, Lachmann PJ and Walport MJ: Systemic lupus erythematosus, complement deficiency, and apoptosis. Adv Immunol. 76:227–324. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Schejbel L, Skattum L, Hagelberg S, Åhlin A, Schiller B, Berg S, Genel F, Truedsson L and Garred P: Molecular basis of hereditary C1q deficiency-revisited: Identification of several novel disease-causing mutations. Genes Immun. 12:626–634. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Buyon J, Furie R, Putterman C, Ramsey-Goldman R, Kalunian K, Barken D, Conklin J and Dervieux T: Reduction in erythrocyte-bound complement activation products and titres of anti-C1q antibodies associate with clinical improvement in systemic lupus erythematosus. Lupus Sci Med. 3:e0001652016. View Article : Google Scholar : PubMed/NCBI

31 

Gilliam BE, Reed MR, Chauhan AK, Dehlendorf AB and Moore TL: Significance of complement components C1q and C4 bound to circulating immune complexes in juvenile idiopathic arthritis: Support for classical complement pathway activation. Clin Exp Rheumatol. 29:1049–1056. 2011.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ding S, Liu C, Li Y, Liu H, Liu Z, Chen T, Zhang T, Shao Z and Fu R: Expression of C1q in the serum of patients with non‑severe aplastic anemia, and its association with disease severity. Mol Med Rep 19: 1194-1202, 2019.
APA
Ding, S., Liu, C., Li, Y., Liu, H., Liu, Z., Chen, T. ... Fu, R. (2019). Expression of C1q in the serum of patients with non‑severe aplastic anemia, and its association with disease severity. Molecular Medicine Reports, 19, 1194-1202. https://doi.org/10.3892/mmr.2018.9754
MLA
Ding, S., Liu, C., Li, Y., Liu, H., Liu, Z., Chen, T., Zhang, T., Shao, Z., Fu, R."Expression of C1q in the serum of patients with non‑severe aplastic anemia, and its association with disease severity". Molecular Medicine Reports 19.2 (2019): 1194-1202.
Chicago
Ding, S., Liu, C., Li, Y., Liu, H., Liu, Z., Chen, T., Zhang, T., Shao, Z., Fu, R."Expression of C1q in the serum of patients with non‑severe aplastic anemia, and its association with disease severity". Molecular Medicine Reports 19, no. 2 (2019): 1194-1202. https://doi.org/10.3892/mmr.2018.9754
Copy and paste a formatted citation
x
Spandidos Publications style
Ding S, Liu C, Li Y, Liu H, Liu Z, Chen T, Zhang T, Shao Z and Fu R: Expression of C1q in the serum of patients with non‑severe aplastic anemia, and its association with disease severity. Mol Med Rep 19: 1194-1202, 2019.
APA
Ding, S., Liu, C., Li, Y., Liu, H., Liu, Z., Chen, T. ... Fu, R. (2019). Expression of C1q in the serum of patients with non‑severe aplastic anemia, and its association with disease severity. Molecular Medicine Reports, 19, 1194-1202. https://doi.org/10.3892/mmr.2018.9754
MLA
Ding, S., Liu, C., Li, Y., Liu, H., Liu, Z., Chen, T., Zhang, T., Shao, Z., Fu, R."Expression of C1q in the serum of patients with non‑severe aplastic anemia, and its association with disease severity". Molecular Medicine Reports 19.2 (2019): 1194-1202.
Chicago
Ding, S., Liu, C., Li, Y., Liu, H., Liu, Z., Chen, T., Zhang, T., Shao, Z., Fu, R."Expression of C1q in the serum of patients with non‑severe aplastic anemia, and its association with disease severity". Molecular Medicine Reports 19, no. 2 (2019): 1194-1202. https://doi.org/10.3892/mmr.2018.9754
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