Radix Sophorae Flavescentis inhibits proliferation and induces apoptosis of AGS human gastric cancer cells

  • Authors:
    • Ji Sun Kim
    • Seung Jae Shin
    • Jung Nam Kim
    • Min Ji Kwon
    • Eun Yeong Lim
    • Yun Tai Kim
    • Hyungwoo Kim
    • Byung Joo Kim
  • View Affiliations

  • Published online on: December 18, 2018     https://doi.org/10.3892/mmr.2018.9776
  • Pages: 1911-1918
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Abstract

Traditional herbal medicines are being increasingly used worldwide to treat cancer. Radix Sophorae Flavescentis (RSF) is a Chinese herb, which has numerous pharmacological properties, including anti‑tumour effects. In this study, we investigated the mechanisms underlying RSF‑induced apoptosis in human gastric cancer cells (AGS cells). We found that RSF treatment (20‑200 µg/ml) inhibited the proliferation of AGS cells and increased the sub‑G1 phase ratio. RSF‑induced cell death was associated with the downregulation of BCl‑2 and upregulation of Bax. In addition to increasing the expression levels of apoptosis‑mediating surface antigen FAS and Fas ligand, RSF also activated caspase‑3; however, mitogen‑activated protein kinase appeared to inhibit RSF‑induced cell death. RSF also led to an increased production of reactive oxygen species. Based on these results, we propose that RSF could be a potential therapeutic agent for gastric cancer.
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March-2019
Volume 19 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Kim JS, Shin SJ, Kim JN, Kwon MJ, Lim EY, Kim YT, Kim H and Kim BJ: Radix Sophorae Flavescentis inhibits proliferation and induces apoptosis of AGS human gastric cancer cells. Mol Med Rep 19: 1911-1918, 2019.
APA
Kim, J.S., Shin, S.J., Kim, J.N., Kwon, M.J., Lim, E.Y., Kim, Y.T. ... Kim, B.J. (2019). Radix Sophorae Flavescentis inhibits proliferation and induces apoptosis of AGS human gastric cancer cells. Molecular Medicine Reports, 19, 1911-1918. https://doi.org/10.3892/mmr.2018.9776
MLA
Kim, J. S., Shin, S. J., Kim, J. N., Kwon, M. J., Lim, E. Y., Kim, Y. T., Kim, H., Kim, B. J."Radix Sophorae Flavescentis inhibits proliferation and induces apoptosis of AGS human gastric cancer cells". Molecular Medicine Reports 19.3 (2019): 1911-1918.
Chicago
Kim, J. S., Shin, S. J., Kim, J. N., Kwon, M. J., Lim, E. Y., Kim, Y. T., Kim, H., Kim, B. J."Radix Sophorae Flavescentis inhibits proliferation and induces apoptosis of AGS human gastric cancer cells". Molecular Medicine Reports 19, no. 3 (2019): 1911-1918. https://doi.org/10.3892/mmr.2018.9776