Open Access

FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition

  • Authors:
    • Ya‑Dong Luo
    • Xu Ding
    • Hong‑Ming Du
    • Yu‑Nong Wu
    • Huai‑Qi Li
    • He‑Ming Wu
    • Xiao‑Min Zhang
  • View Affiliations

  • Published online on: March 27, 2019     https://doi.org/10.3892/mmr.2019.10094
  • Pages: 4101-4108
  • Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Although forkhead box protein M1 (FOXM1) is markedly upregulated in human premalignant and oral squamous cell carcinoma (OSCC) tissues and cultured cells, the association of FOXM1 expression with OSCC prognosis is not well understood. The present study investigated the possible association of FOXM1 expression in patients with OSCC with their clinicopathological characteristics and clinical outcomes. The expression of FOXM1 protein in OSCC tissues from 119 patients was evaluated by immunohistochemistry, and the results demonstrated that FOXM1 overexpression in patients with OSCC was associated with tumour recurrence and poor prognosis. To study the in vitro effects of FOXM1, its expression was decreased by small interfering RNA (siRNA) in OSCC cell lines, and FOXM1 knockdown decreased the proliferative, migratory and invasive capacities of cells. FOXM1 inhibition by siRNA gave rise to reduced expression of vimentin and increased expression of E‑cadherin. The present study reported FOXM1 as a novel predictor of tumour recurrence in patients with OSCC and its potential involvement in epithelial‑mesenchymal transition in OSCC cells.
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May-2019
Volume 19 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Luo YD, Ding X, Du HM, Wu YN, Li HQ, Wu HM and Zhang XM: FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition. Mol Med Rep 19: 4101-4108, 2019.
APA
Luo, Y., Ding, X., Du, H., Wu, Y., Li, H., Wu, H., & Zhang, X. (2019). FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition. Molecular Medicine Reports, 19, 4101-4108. https://doi.org/10.3892/mmr.2019.10094
MLA
Luo, Y., Ding, X., Du, H., Wu, Y., Li, H., Wu, H., Zhang, X."FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition". Molecular Medicine Reports 19.5 (2019): 4101-4108.
Chicago
Luo, Y., Ding, X., Du, H., Wu, Y., Li, H., Wu, H., Zhang, X."FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelial‑mesenchymal transition". Molecular Medicine Reports 19, no. 5 (2019): 4101-4108. https://doi.org/10.3892/mmr.2019.10094