Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus

  • Authors:
    • Lina Liu
    • Jing Yan
    • Fei Ge
    • Xiangtao Xu
    • Jun Lu
    • Huilian Shi
    • Shuihong Li
    • Yue Zhao
    • Changzheng Zhang
  • View Affiliations

  • Published online on: May 10, 2019     https://doi.org/10.3892/mmr.2019.10232
  • Pages: 332-340
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Abstract

Saikosaponin‑D (SSD), which is the main bioactive component in the traditional Chinese medicine Chai Hu (Bupleurum falcatum L), possesses estrogen‑like properties and is widely used in treating estrogen‑related neurological disorders. The current study aimed to investigate the protective effects of SSD on the fear memory deficit in ovariectomized (OVX) rats and the potential underlying mechanism. SSD treatment significantly prolonged freezing time in OVX rats in a manner similar to that of estradiol (E2), whereas this effect was markedly suppressed by co‑administration of ICI182780, a non‑selective estrogen receptor (ER) inhibitor. The expression of ERα in the hippocampus of OVX rats was significantly elevated by SSD; however, Erβ expression and E2 synthesis were not markedly affected by SSD treatment. Collectively, this study demonstrated that SSD‑mediated fear memory improvement in OVX rats may be attributed not to E2 levels or ERβ activity, but to ERα activation in the hippocampus.
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July-2019
Volume 20 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Liu L, Yan J, Ge F, Xu X, Lu J, Shi H, Li S, Zhao Y and Zhang C: Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus. Mol Med Rep 20: 332-340, 2019.
APA
Liu, L., Yan, J., Ge, F., Xu, X., Lu, J., Shi, H. ... Zhang, C. (2019). Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus. Molecular Medicine Reports, 20, 332-340. https://doi.org/10.3892/mmr.2019.10232
MLA
Liu, L., Yan, J., Ge, F., Xu, X., Lu, J., Shi, H., Li, S., Zhao, Y., Zhang, C."Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus". Molecular Medicine Reports 20.1 (2019): 332-340.
Chicago
Liu, L., Yan, J., Ge, F., Xu, X., Lu, J., Shi, H., Li, S., Zhao, Y., Zhang, C."Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus". Molecular Medicine Reports 20, no. 1 (2019): 332-340. https://doi.org/10.3892/mmr.2019.10232