Development of a novel method for visualizing restricted diffusion using subtraction of apparent diffusion coefficient values

Yoshimura,Yuuki; Kuroda,Masahiro; Sugianto,Irfan; Khasawneh,Abdullah; Bamgbose,Babatunde  O.; Hamada,Kentaro; Barham,Majd; Tekiki,Nouha; Kurozumi,Akira; Matsushita,Toshi; Ohno,Seiichiro; Kanazawa,Susumu; Asaumi,Junichi

doi:10.3892/mmr.2019.10523

Development of a novel method for visualizing restricted diffusion using subtraction of apparent diffusion coefficient values

Authors:
- Yuuki Yoshimura
- Masahiro Kuroda
- Irfan Sugianto
- Abdullah Khasawneh
- Babatunde O. Bamgbose
- Kentaro Hamada
- Majd Barham
- Nouha Tekiki
- Akira Kurozumi
- Toshi Matsushita
- Seiichiro Ohno
- Susumu Kanazawa
- Junichi Asaumi
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Affiliations: Department of Radiological Technology, Graduate School of Health Sciences, Okayama University, Okayama 7008558, Japan, Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 7008558, Japan, Central Division of Radiology, Okayama University Hospital, Okayama 7008558, Japan, Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 7008558, Japan
Published online on: July 25, 2019 https://doi.org/10.3892/mmr.2019.10523
Pages: 2963-2969

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Abstract

In order to visualize restricted diffusion, the present study developed a novel method called ‘apparent diffusion coefficient (ADC) subtraction method (ASM)’ and compared it with diffusion kurtosis imaging (DKI). The diffusion-weighted images of physiological saline, in addtion to bio-phatoms of low cell density and the highest cell density were obtained using two sequences with different effective diffusion times. Then, the calculated ADC values were subtracted. The mean values and standard deviations (SD) of the ADC values of physiological saline, low cell density and the highest cell density phantoms were 2.95±0.08x10‑3, 1.90±0.35x10‑3 and 0.79±0.05x10‑3 mm2/sec, respectively. The mean kurtosis values and SD of DKI were 0.04±0.01, 0.44±0.13 and 1.27±0.03, respectively. The ASM and SD values were 0.25±0.20x104, 0.51±0.41x104 and 4.80±4.51x104 (sec/mm2)2, respectively. Using bio‑phantoms, the present study demonstrated that DKI exhibits restricted diffusion in the extracellular space. Similarly, ASM may reflect the extent of restricted diffusion in the extracellular space.

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