Open Access

BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44

  • Authors:
    • Lei Gao
    • Hansong Liu
    • Ningwei Yin
    • Shanshan Zuo
    • Guangli Jin
    • Yangxi Hu
    • Desheng Hu
    • Ying Li
    • Qiong Song
    • Xuejie Fei
  • View Affiliations

  • Published online on: September 2, 2019     https://doi.org/10.3892/mmr.2019.10633
  • Pages: 4073-4080
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) currently leads to many deaths worldwide. The regulatory mechanism, however, remains largely unclear. In the present study, bioinformatics methods were used to identify genes associated with CRC prognosis and to detect the molecular signals regulating the cell cycle in two CRC cell lines. It was revealed that BNIPL‑2 expression was higher in CRC tissues than in adjacent tissue samples. Upregulation of BNIPL‑2 was correlated with poor prognosis and the adverse malignant stages T and M. BNIPL‑2 was also associated with signaling pathways involved in cancer cell growth. BNIPL‑2 overexpression promoted cell proliferation and increased the proportion of cells in the G2/M phase. Knockdown of BNIPL‑2 inhibited cell proliferation. CD44 was regulated by BNIPL‑2 and promoted cell proliferation. Downregulation of CD44 suppressed cell proliferation and rescued the cell proliferation promoted by BNIPL‑2. Overexpression of CD44 restored the cell proliferation suppressed by BNIPL‑2 knockdown. The present study not only suggested that BNIPL‑2 may be a potential biomarker of CRC but also indicated that BNIPL‑2 regulates CRC cancer proliferation via CD44, which could be a diagnostic and clinical treatment target.
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November-2019
Volume 20 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Gao L, Liu H, Yin N, Zuo S, Jin G, Hu Y, Hu D, Li Y, Song Q, Fei X, Fei X, et al: BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44. Mol Med Rep 20: 4073-4080, 2019.
APA
Gao, L., Liu, H., Yin, N., Zuo, S., Jin, G., Hu, Y. ... Fei, X. (2019). BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44. Molecular Medicine Reports, 20, 4073-4080. https://doi.org/10.3892/mmr.2019.10633
MLA
Gao, L., Liu, H., Yin, N., Zuo, S., Jin, G., Hu, Y., Hu, D., Li, Y., Song, Q., Fei, X."BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44". Molecular Medicine Reports 20.5 (2019): 4073-4080.
Chicago
Gao, L., Liu, H., Yin, N., Zuo, S., Jin, G., Hu, Y., Hu, D., Li, Y., Song, Q., Fei, X."BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44". Molecular Medicine Reports 20, no. 5 (2019): 4073-4080. https://doi.org/10.3892/mmr.2019.10633