Open Access

TAFA5 promotes proliferation and migration in gastric cancer

  • Authors:
    • Zhiqing Hu
    • Gengming Niu
    • Jun Ren
    • Xin Wang
    • Liang Chen
    • Runqi Hong
    • Chongwei Ke
  • View Affiliations

  • Published online on: October 2, 2019     https://doi.org/10.3892/mmr.2019.10724
  • Pages: 4477-4488
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

TAFA chemokine like family member 5 (TAFA5), a TAFA family member that encodes small secreted proteins in the central nervous system, has been demonstrated to have increased expression in human malignancies. However, the expression and function of TAFA5 in gastric cancer (GC) remains unclear. In the present study, public datasets and human GC samples were used to determine the TAFA5 expression levels. The results revealed that TAFA5 was upregulated in GC when compared with adjacent normal tissues. Overexpression of TAFA5 in GC was associated with poor differentiation, and worse tumor, nodal and metastasis stages. In addition, high TAFA5 expression was correlated with unfavorable patient prognoses. In vitro experiments indicated that downregulation of TAFA5 inhibited the proliferation and migration of GC cell lines. Finally, the results from gene set enrichment analysis using data from The Cancer Genome Atlas revealed that TAFA5 expression was significantly correlated with genes associated with epithelial‑mesenchymal transition, which was further confirmed by western blot analysis. In conclusion, the results of the present study suggested that TAFA5 had significant effects on GC progression, suggesting that it may serve as a potential therapeutic target for GC therapy.
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November-2019
Volume 20 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Hu Z, Niu G, Ren J, Wang X, Chen L, Hong R and Ke C: TAFA5 promotes proliferation and migration in gastric cancer . Mol Med Rep 20: 4477-4488, 2019
APA
Hu, Z., Niu, G., Ren, J., Wang, X., Chen, L., Hong, R., & Ke, C. (2019). TAFA5 promotes proliferation and migration in gastric cancer . Molecular Medicine Reports, 20, 4477-4488. https://doi.org/10.3892/mmr.2019.10724
MLA
Hu, Z., Niu, G., Ren, J., Wang, X., Chen, L., Hong, R., Ke, C."TAFA5 promotes proliferation and migration in gastric cancer ". Molecular Medicine Reports 20.5 (2019): 4477-4488.
Chicago
Hu, Z., Niu, G., Ren, J., Wang, X., Chen, L., Hong, R., Ke, C."TAFA5 promotes proliferation and migration in gastric cancer ". Molecular Medicine Reports 20, no. 5 (2019): 4477-4488. https://doi.org/10.3892/mmr.2019.10724