Syntenin regulates melanogenesis via the p38 MAPK pathway

Sun,Lijun; Guo,Chunyan; Yan,Liting; Li,Huijin; Sun,Jingying; Huo,Xueping; Xie,Xin; Hu,Jun

doi:10.3892/mmr.2020.11139

Syntenin regulates melanogenesis via the p38 MAPK pathway

Authors:
- Lijun Sun
- Chunyan Guo
- Liting Yan
- Huijin Li
- Jingying Sun
- Xueping Huo
- Xin Xie
- Jun Hu
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Affiliations: Central Laboratory of Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China, Institute of Basic and Translational Medicine, Xi'an Medical University, Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Xi'an, Shaanxi 710021, P.R. China, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, P.R. China
Published online on: May 7, 2020 https://doi.org/10.3892/mmr.2020.11139
Pages: 733-738
Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Melanogenesis is the synthesis of the skin pigment melanin, which serves a critical role in the study of pigmentary skin diseases. Syntenin has been identified as a melanosome protein, but its role in melanogenesis is not completely understood. The present study aimed to investigate the effects and mechanisms underlying syntenin on melanogenesis in immortalized human melanocytes. Depletion of syntenin expression increased both tyrosinase (Tyr) activity and melanin content. Syntenin silencing also increased the protein expression levels of Tyr, pre‑melanosomal protein and microphthalmia‑associated transcription factor. In addition, the results indicated that syntenin regulated melanogenesis by upregulating the phosphorylation of p38 mitogen‑activated protein kinase (p38 MAPK). Taken together, these findings suggested that the regulation of melanogenesis by syntenin may be mediated by the activation of p38 MAPK and that syntenin might provide new insights into the pathogenesis of pigmented diseases.

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