Open Access

Telomerase and telomeres in aging theory and chronographic aging theory (Review)

  • Authors:
    • Mayya P. Razgonova
    • Alexander M. Zakharenko
    • Kirill S. Golokhvast
    • Maria Thanasoula
    • Evangelia Sarandi
    • Konstantinos Nikolouzakis
    • Persefoni Fragkiadaki
    • Dimitris Tsoukalas
    • Demetrios A. Spandidos
    • Aristidis Tsatsakis
  • View Affiliations

  • Published online on: June 25, 2020     https://doi.org/10.3892/mmr.2020.11274
  • Pages: 1679-1694
  • Copyright: © Razgonova et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The current review focuses on the connection of telomerase and telomeres with aging. In this review, we describe the changes in telomerase and telomere length (TEL) during development, their role in carcinogenesis processes, and the consequences of reduced telomerase activity. More specifically, the connection of TEL in peripheral blood cells with the development of aging‑associated diseases is discussed. The review provides systematic data on the role of telomerase in mitochondria, the biology of telomeres in stem cells, as well as the consequences of the forced expression of telomerase (telomerization) in human cells. Additionally, it presents the effects of chronic stress exposure on telomerase activity, the effect of TEL on fertility, and the effect of nutraceutical supplements on TEL. Finally, a comparative review of the chronographic theory of aging, presented by Olovnikov is provided based on currently available scientific research on telomere, telomerase activity, and the nature of aging by multicellular organisms.
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September-2020
Volume 22 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Razgonova MP, Zakharenko AM, Golokhvast KS, Thanasoula M, Sarandi E, Nikolouzakis K, Fragkiadaki P, Tsoukalas D, Spandidos DA, Tsatsakis A, Tsatsakis A, et al: Telomerase and telomeres in aging theory and chronographic aging theory (Review). Mol Med Rep 22: 1679-1694, 2020.
APA
Razgonova, M.P., Zakharenko, A.M., Golokhvast, K.S., Thanasoula, M., Sarandi, E., Nikolouzakis, K. ... Tsatsakis, A. (2020). Telomerase and telomeres in aging theory and chronographic aging theory (Review). Molecular Medicine Reports, 22, 1679-1694. https://doi.org/10.3892/mmr.2020.11274
MLA
Razgonova, M. P., Zakharenko, A. M., Golokhvast, K. S., Thanasoula, M., Sarandi, E., Nikolouzakis, K., Fragkiadaki, P., Tsoukalas, D., Spandidos, D. A., Tsatsakis, A."Telomerase and telomeres in aging theory and chronographic aging theory (Review)". Molecular Medicine Reports 22.3 (2020): 1679-1694.
Chicago
Razgonova, M. P., Zakharenko, A. M., Golokhvast, K. S., Thanasoula, M., Sarandi, E., Nikolouzakis, K., Fragkiadaki, P., Tsoukalas, D., Spandidos, D. A., Tsatsakis, A."Telomerase and telomeres in aging theory and chronographic aging theory (Review)". Molecular Medicine Reports 22, no. 3 (2020): 1679-1694. https://doi.org/10.3892/mmr.2020.11274