lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis

Zhang,Xifeng; Zou,Ying; Zheng,Jiangxia; Ji,Senguo; Wen,Xiuzhen; Ye,Feng; Liu,Ju; Li,Xueyong; Lei,Jin; Qiu,Mingliang

doi:10.3892/mmr.2020.11314

lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis

Authors:
- Xifeng Zhang
- Ying Zou
- Jiangxia Zheng
- Senguo Ji
- Xiuzhen Wen
- Feng Ye
- Ju Liu
- Xueyong Li
- Jin Lei
- Mingliang Qiu
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Affiliations: Department of Rheumatism and Immunology of The First People’s Hospital, Jiujiang, Jiangxi 332000, P.R. China, Department of Rheumatology, Xuzhou Hospital of Traditional Chinese Medicine, Xuzhou, Jiangsu 221009, P.R. China, Department of Rheumatology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006, P.R. China
Published online on: July 9, 2020 https://doi.org/10.3892/mmr.2020.11314
Pages: 2227-2234
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute gouty arthritis (AGA) is characterized by the accumulation of pro‑inflammatory cytokines, which are immunological responses to monosodium urate (MSU) crystals. It has been demonstrated that long non‑coding RNA (lncRNA)‑MM2P is a novel regulator of M2 polarization of macrophages. The aim of the present study was to investigate whether lncRNA‑MM2P regulates the MSU‑induced inflammatory process. In cell models of RAW 264.7 and THP‑1‑derived macrophages, decreased expression of lncRNA‑MM2P was observed in lipopolysaccharide‑ and MSU‑treated macrophages, which was accompanied with obvious inflammatory responses. Using small interfering RNA to knockdown lncRNA‑MM2P led to the upregulation of MSU‑mediated inflammatory responses, both in RAW 264.7 and THP‑1‑derived macrophages. In conclusion, lncRNA‑MM2P could be an important regulator of MSU‑induced inflammation, and therefore could be involved in the development of AGA.

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