Open Access

Electroacupuncture pre‑conditioning protects from lung injury induced by limb ischemia/reperfusion through TLR4 and NF‑κB in rats

  • Authors:
    • Yingying Lou
    • Qimin Yu
    • Kaiwei Xu
    • Yingying Tu
    • Meita Felicia Balelang
    • Guangtao Lu
    • Congying Zhu
    • Qinxue Dai
    • Wujun Geng
    • Yunchang Mo
    • Junlu Wang
  • View Affiliations

  • Published online on: August 12, 2020     https://doi.org/10.3892/mmr.2020.11429
  • Pages: 3225-3232
  • Copyright: © Lou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Limb ischemia/reperfusion (I/R) can induce inflammation, causing acute lung injury. The Toll‑like receptor 4 (TLR4)/NF‑κB pathway plays an important role in acute and chronic inflammatory disorders. Several studies have demonstrated the efficacy of acupuncture in lung inflammatory injury. The aim of the present study was to elucidate the mechanism underlying the protective effect of electroacupuncture (EA) against lung injury induced by limb I/R. EA applied at the Zusanli and Sanyinjiao acupoints attenuated lung injury and decreased the secretion of inflammatory factors such as tumor necrosis factor‑α, interleukin (IL)‑1, IL‑6 and myeloperoxidase. Moreover, the expression levels of TLR4 and NF‑κB were suppressed by EA. Thus, the present findings suggested that EA can reduce pulmonary inflammation induced by limb I/R injury, possibly via the inhibition of the TLR4/NF‑κB pathway.
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October-2020
Volume 22 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Lou Y, Yu Q, Xu K, Tu Y, Balelang MF, Lu G, Zhu C, Dai Q, Geng W, Mo Y, Mo Y, et al: Electroacupuncture pre‑conditioning protects from lung injury induced by limb ischemia/reperfusion through TLR4 and NF‑κB in rats. Mol Med Rep 22: 3225-3232, 2020.
APA
Lou, Y., Yu, Q., Xu, K., Tu, Y., Balelang, M.F., Lu, G. ... Wang, J. (2020). Electroacupuncture pre‑conditioning protects from lung injury induced by limb ischemia/reperfusion through TLR4 and NF‑κB in rats. Molecular Medicine Reports, 22, 3225-3232. https://doi.org/10.3892/mmr.2020.11429
MLA
Lou, Y., Yu, Q., Xu, K., Tu, Y., Balelang, M. F., Lu, G., Zhu, C., Dai, Q., Geng, W., Mo, Y., Wang, J."Electroacupuncture pre‑conditioning protects from lung injury induced by limb ischemia/reperfusion through TLR4 and NF‑κB in rats". Molecular Medicine Reports 22.4 (2020): 3225-3232.
Chicago
Lou, Y., Yu, Q., Xu, K., Tu, Y., Balelang, M. F., Lu, G., Zhu, C., Dai, Q., Geng, W., Mo, Y., Wang, J."Electroacupuncture pre‑conditioning protects from lung injury induced by limb ischemia/reperfusion through TLR4 and NF‑κB in rats". Molecular Medicine Reports 22, no. 4 (2020): 3225-3232. https://doi.org/10.3892/mmr.2020.11429