Estrogen receptor-associated receptor α and peroxisome proliferator-activated receptor γ in metabolism and disease (Review)

  • Authors:
    • Wei-Yi Huang
    • Peng-Ming Sun
  • View Affiliations

  • Published online on: December 22, 2020     https://doi.org/10.3892/mmr.2020.11795
  • Article Number: 156
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Estrogen receptor‑associated receptor α (ERRα) is an orphan nuclear receptor that lacks corresponding ligands. ERRα recruits co‑regulators to regulate gene transcription and plays an important role in human physiological functions. Peroxisome proliferator‑activated receptor γ (PPARγ) is also a nuclear receptor that regulates the expression of target genes via a ligand‑dependent mechanism, thereby participating in a series of physiological processes. Both ERRα and PPARγ are involved in the process of energy metabolism and tumorigenesis. In the present review, a concise overview of the important roles governed by ERRα and PPARγ in metabolism and their association with various disease are provided.
View Figures
View References

Related Articles

Journal Cover

February-2021
Volume 23 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Huang W and Sun P: Estrogen receptor-associated receptor α and peroxisome proliferator-activated receptor γ in metabolism and disease (Review). Mol Med Rep 23: 156, 2021.
APA
Huang, W., & Sun, P. (2021). Estrogen receptor-associated receptor α and peroxisome proliferator-activated receptor γ in metabolism and disease (Review). Molecular Medicine Reports, 23, 156. https://doi.org/10.3892/mmr.2020.11795
MLA
Huang, W., Sun, P."Estrogen receptor-associated receptor α and peroxisome proliferator-activated receptor γ in metabolism and disease (Review)". Molecular Medicine Reports 23.2 (2021): 156.
Chicago
Huang, W., Sun, P."Estrogen receptor-associated receptor α and peroxisome proliferator-activated receptor γ in metabolism and disease (Review)". Molecular Medicine Reports 23, no. 2 (2021): 156. https://doi.org/10.3892/mmr.2020.11795