Open Access

HIF‑1α in myocardial ischemia‑reperfusion injury (Review)

  • Authors:
    • Jie Zheng
    • Peier Chen
    • Jianfeng Zhong
    • Yu Cheng
    • Hao Chen
    • Yuan He
    • Can Chen
  • View Affiliations

  • Published online on: March 12, 2021     https://doi.org/10.3892/mmr.2021.11991
  • Article Number: 352
  • Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Myocardial ischemia‑reperfusion injury (MIRI) is a severe injury to the ischemic myocardium following the recovery of blood flow. Currently, there is no effective treatment for MIRI in clinical practice. Over the past two decades, biological studies of hypoxia and hypoxia‑inducible factor‑1α (HIF‑1α) have notably improved understanding of oxygen homeostasis. HIF‑1α is an oxygen‑sensitive transcription factor that mediates adaptive metabolic responses to hypoxia and serves a pivotal role in MIRI. In particular, previous studies have demonstrated that HIF‑1α improves mitochondrial function, decreases cellular oxidative stress, activates cardioprotective signaling pathways and downstream protective genes and interacts with non‑coding RNAs. The present review summarizes the roles and associated mechanisms of action of HIF‑1α in MIRI. In addition, HIF‑1α‑associated MIRI intervention, including natural compounds, exosomes, ischemic preconditioning and ischemic post‑processing are presented. The present review provides evidence for the roles of HIF‑1α activation in MIRI and supports its use as a therapeutic target.
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May-2021
Volume 23 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zheng J, Chen P, Zhong J, Cheng Y, Chen H, He Y and Chen C: HIF‑1α in myocardial ischemia‑reperfusion injury (Review). Mol Med Rep 23: 352, 2021.
APA
Zheng, J., Chen, P., Zhong, J., Cheng, Y., Chen, H., He, Y., & Chen, C. (2021). HIF‑1α in myocardial ischemia‑reperfusion injury (Review). Molecular Medicine Reports, 23, 352. https://doi.org/10.3892/mmr.2021.11991
MLA
Zheng, J., Chen, P., Zhong, J., Cheng, Y., Chen, H., He, Y., Chen, C."HIF‑1α in myocardial ischemia‑reperfusion injury (Review)". Molecular Medicine Reports 23.5 (2021): 352.
Chicago
Zheng, J., Chen, P., Zhong, J., Cheng, Y., Chen, H., He, Y., Chen, C."HIF‑1α in myocardial ischemia‑reperfusion injury (Review)". Molecular Medicine Reports 23, no. 5 (2021): 352. https://doi.org/10.3892/mmr.2021.11991